77455-58-4

Upstream product

• 38939-88-7 2-chloro-4-methyl-1-nitrobenzene 
• 77455-53-9 Acetic acid acetoxy-(3-chloro-4-nitro-phenyl)-methyl ester 
• 67-66-3 chloroform 
• 88-73-3 2-Chloronitrobenzene 
• 57507-34-3 3-chloro-4-nitrobenzaldehyde 

Downstream Products

• 77455-59-5 3-chloro-4-nitrobenzyl chloride 
• 77455-64-2 3-chloro-4-nitrobenzyl ethyl ether 
• 77455-63-1 3,3'-dichloro-4,4'-dinitrodiphenylacetylene 
• 77455-60-8 1,2-bis-(3-chloro-4-nitrophenyl)tetrachloroethane 
• 77455-62-0 (Z)-α,α',3,3'-tetrachloro-4,4'-dinitrostilbene 
• 77455-61-9 (E)-α,α',3,3'-tetrachloro-4,4'-dinitrostilbene 

Relevant academic research and scientific papers

Dihalomethylation of Nitroarenes via Vicarious Nucleophilic Substitution of Hydrogen with Trihalomethyl Carbanions

Trichloro- and tribromomethyl carbanions generated by deprotonation of haloforms with potassium tert-butoxide in a THF-DMF mixture at ca. -70 deg C react with a variety of carbocyclic and heterocyclic nitroarenes according to the vicarious nucleophilic substitution scheme.The reaction provides an efficient and convenient way for the direct introduction of dihalomethyl substituents ortho and para to the nitro group, which in turn can be hydrolyzed to produce nitroaryl aldehydes.

Comparative Reactivity of Substituted 4-Nitrobenzylidene Dichlorides with Alkali

A comparative study of the reactions of substituted 4-nitrobenzylidene dichlorides ArCHCl2 (Ar = 3-Cl-4-NO2C6H3, 2-Cl-4-NO2C6H3, 4-NO2C6H4, 3,5-Me2-4-NO2C6H2, and 2-Me-4-NO2C6H3) with aqueous alcoholic alkali shows that chlorine substitution enhances the