7749-47-5 Usage
Chemical Properties
white to pinkish or light beige
Uses
2-Amino-4-methoxy-6-methylpyrimidine may be employed as nucleophile to investigate the regioselective introduction of some nucleophiles at the secondary position of Baylis-Hillman adducts. It may be used in the preparation of 2-amino-4-methoxy-6-methylpyrimidin-1-ium picrate.
General Description
2-Amino-4-methoxy-6-methylpyrimidine (AMMP) is a pyrimidine derivative. It acts as electron donor and forms charge transfer complexes with iodine (σ-electron acceptor). The FTIR and FT-Raman spectra of 2-amino-4-methoxy-6-methylpyrimidine have been recorded to evaluate the energy, structural and thermodynamical parameters. Molecules of AMMP exhibit space group of Pnma and are joined by two N-H…N hydrogen bonds.
Purification Methods
Recrystallise it from H2O. The picrate has m 220-221o(dec). [Baker et al. J Am pKEst ~ Chem Soc 69 3072, 3075 1947, Sirakawa et al. Yakugaku Zasshi 73 598 1953, Backer & Grevenstuk Recl Trav Chim, Pays-Bas 61 291 1942, Beilstein 25 III/IV 3385.]
Check Digit Verification of cas no
The CAS Registry Mumber 7749-47-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,7,4 and 9 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 7749-47:
(6*7)+(5*7)+(4*4)+(3*9)+(2*4)+(1*7)=135
135 % 10 = 5
So 7749-47-5 is a valid CAS Registry Number.
InChI:InChI=1/C6H9N3O/c1-4-3-5(10-2)9-6(7)8-4/h3H,1-2H3,(H2,7,8,9)
7749-47-5Relevant articles and documents
Research on heterocyclic compounds. XXXII. Synthesis and cyclooxygenase-independent antiinflammatory and analgesic activity of imidazopyrimidine derivatives
Abignente, E.,Sacchi, A.,Laneri, S.,Rossi, F.,D'Amico, M.,et al.
, p. 279 - 286 (2007/10/02)
The synthesis of a group of imidazopyrimidine-2-carboxylic esters, acids and amides is described.The structures of the new compounds are supported by 1H- and 13C-NMR spectra.These compounds were tested in vivo for their antiinflammatory and analgesic activities as well as for their ulcerogenic action.The ester 5b, the acid 6c and the amide 7a showed antiinflammatory action in the rat paw edema (ca. 1/3 x indomethacin), while almost all compounds displayed significant analgesic activity in the acetic acid writhing test, particularly the 5-chloro-7-methyl derivatives 5a, 6a and 7a (ca 1/5 x indomethacin).All new compounds were found to be lacking in inhibitory activity on cyclooxygenase in vitro. imidazopyrimidines / antiinflammatory activity / analgesic activity / ulcerogenic activity / cyclooxygenase inhibition
