7749-47-5

Usage

Uses

Used in Chemical Synthesis:
2-Amino-4-methoxy-6-methylpyrimidine is used as a nucleophile for the regioselective introduction of certain nucleophiles at the secondary position of Baylis-Hillman adducts. This application is significant in the field of organic chemistry, where regioselectivity is crucial for the synthesis of specific target molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Amino-4-methoxy-6-methylpyrimidine is utilized in the preparation of 2-amino-4-methoxy-6-methylpyrimidin-1-ium picrate. 2-Amino-4-methoxy-6-methylpyrimidine may have potential applications in the development of new drugs or drug candidates, contributing to the advancement of medicinal chemistry.
Used in Material Science:
The study of 2-Amino-4-methoxy-6-methylpyrimidine through FTIR and FT-Raman spectra allows for the evaluation of its energy, structural, and thermodynamical parameters. This information can be valuable in material science, where understanding the properties of compounds at a molecular level can lead to the development of new materials with specific characteristics and applications.

Purification Methods

Recrystallise it from H2O. The picrate has m 220-221o(dec). [Baker et al. J Am pKEst ~ Chem Soc 69 3072, 3075 1947, Sirakawa et al. Yakugaku Zasshi 73 598 1953, Backer & Grevenstuk Recl Trav Chim, Pays-Bas 61 291 1942, Beilstein 25 III/IV 3385.]

InChI:InChI=1/C6H9N3O/c1-4-3-5(10-2)9-6(7)8-4/h3H,1-2H3,(H2,7,8,9)

Upstream product

• 5600-21-5 2-amino-6-methyl-4-chloropyrimidine 
• 124-41-4 sodium methylate 
• 67-56-1 methanol 
• 70-23-5 ethyl Bromopyruvate 

Downstream Products

• 121583-46-8 N-<(4-Methoxy-6-methylpyrimidin-2-ylamino)-2,2,2-trichlorethyl>-2-methoxybenzolsaeureamid 
• 121583-57-1 N-<(4-Methoxy-6-methylpyrimidin-2-ylamino)-2,2,2-trichlorethyl>-2,6-difluorbenzolsulfonsaeureamid 
• 121583-51-5 2-aminosulfonyl>benzoesaeuremethylester 
• 121583-53-7 N-<(4-Methoxy-6-methylpyrimidin-2-ylamino)-2,2,2-trichlorethyl>-2-nitrobenzolsulfonsaeureamid 
• 353302-84-8 2-(4-chlorobenzenesulfonylamido)-4-methoxy-6-methylpyrimidine 
• 330946-56-0 4-methoxy-6-methyl-2-p-toluenesulfonylamidopyrimidine 
• 312597-84-5 2-benzenesulfonylamido-4-methoxy-6-methylpyrimidine 
• 130240-03-8 2-(2-chlorobenzenesulfonylamido)-4-methoxy-6-methylpyrimidine 
• 334506-05-7 N-(4-hydrazino-6-methyl-pyrimidin-2-yl)-benzenesulfonamide 
• 328071-28-9 N-(4-azido-6-methyl-pyrimidin-2-yl)-4-methyl-benzenesulfonamide 
• 334506-06-8 4-chloro-N-(4-hydrazino-6-methyl-pyrimidin-2-yl)-benzenesulfonamide 
• 334506-13-7 2-chloro-N-(4-hydrazino-6-methyl-pyrimidin-2-yl)-benzenesulfonamide 
• 334506-14-8 5-chloro-4-methoxy-6-methyl-2-p-toluenesulfonylamidopyrimidine 
• 334506-08-0 N-(4-hydrazino-6-methyl-pyrimidin-2-yl)-4-methyl-benzenesulfonamide 

Relevant academic research and scientific papers

Research on heterocyclic compounds. XXXII. Synthesis and cyclooxygenase-independent antiinflammatory and analgesic activity of imidazopyrimidine derivatives

The synthesis of a group of imidazopyrimidine-2-carboxylic esters, acids and amides is described.The structures of the new compounds are supported by 1H- and 13C-NMR spectra.These compounds were tested in vivo for their antiinflammatory and analgesic activities as well as for their ulcerogenic action.The ester 5b, the acid 6c and the amide 7a showed antiinflammatory action in the rat paw edema (ca. 1/3 x indomethacin), while almost all compounds displayed significant analgesic activity in the acetic acid writhing test, particularly the 5-chloro-7-methyl derivatives 5a, 6a and 7a (ca 1/5 x indomethacin).All new compounds were found to be lacking in inhibitory activity on cyclooxygenase in vitro. imidazopyrimidines / antiinflammatory activity / analgesic activity / ulcerogenic activity / cyclooxygenase inhibition

Process for producing sulfonylureas

There is described a novel process for producing sulfonylureas of formula I STR1 wherein R1 is hydrogen or alkyl, R2 is STR2 E is =N-- or =CH--, R3 is alkyl, alkoxy or halogen, R4 is alkyl, cycloalkyl, alkoxy, halogen, alkoxy-alkyl, halo-alkyl or halo-alkoxy, R5 is hydrogen or alkyl, T is a substituted phenyl group STR3 Y is hydrogen or halogen, X is hydrogen, halogen, alkyl, halo-alkyl, alkenyl, halo-alkenyl, alkynyl, alkoxy, halo-alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, halo-alkylthio, alkylsulfonyloxy, phenylsulfonyloxy, phenylsulfonyloxy mono- or polysubstituted by alkyl, or is di-alkylsulfamoyl, and A is a bridge member which has 3 or 4 atoms and which contains 1 or 2 hetero atoms, selected from the group consisting of oxygen, sulfur and nitrogen, the said process comprising reacting a silfonamide of the formula II in the presence of a base, with diphenyl carbonate to form a salt of a phenyl carbamate converting this salt into the free phenyl carbamate and reacting this further with an amine. Sulfonylureas are herbicidally effective compounds.