775-01-9

Basic information

• Product Name: 3,4-Dihydroxymandelic acid
• Synonyms: 3,4-dihydroxymandelic acid;2-(3,4-dihydroxyphenyl)-2-hydroxy-acetic acid;α,3,4-Trihydroxybenzeneacetic acid;C07470;Dihydroxymandelic acid;rac 3,4-DihydroxyMandelic Acid;DL-3,4-Dihydroxymandelic Acid
• CAS NO: 775-01-9
• Molecular Formula: C₈H₈O₅
• Molecular Weight: 184.15
• EINECS: 212-269-3
• Product Categories: Aromatics;Miscellaneous Reagents
• Mol File: 775-01-9.mol
• Article Data: 9

Chemical Properties

• Melting Point: 136-137 °C (dec.)
• Boiling Point: 487.5 °C at 760 mmHg
• Flash Point: 262.7 °C
• Appearance: /
• Density: 1.644 g/cm³
• Storage Temp.: -20?C Freezer, Under Inert Atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 3.42±0.10(Predicted)
• Stability: Light , Temperature and Air Sensitive
• CAS DataBase Reference: 3,4-Dihydroxymandelic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-Dihydroxymandelic acid(775-01-9)
• EPA Substance Registry System: 3,4-Dihydroxymandelic acid(775-01-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 775-01-9(Hazardous Substances Data)

Usage

Uses

A protein kinase C inhibitor.

Definition

ChEBI: A catechol that is the 3,4-dihydroxy derivative of mandelic acid; a metabolite of L-dopa.

InChI:InChI=1/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13)

Upstream product

• 120-80-9 benzene-1,2-diol 
• 298-12-4 Glyoxilic acid 
• 117279-29-5 2-(3,4-carbonyldioxyphenyl)-2-chloroacetic acid 
• 67-64-1 acetone 

Downstream Products

• 335591-55-4 3,4-dihydroxymandelic acid N-succinimidyl ester 
• 99-50-3 3,4-Dihydroxybenzoic acid 
• 139-85-5 3,4-dihydroxybenzaldehyde 
• 29413-65-8 methyl 2-(3,4-dihydroxyphenyl)-2-hydroxyacetate 
• 96657-18-0 2-Chloro-4,5-dihydroxymandelic acid 
• 621-59-0 isovanillin 
• 121-33-5 vanillin 
• 120-57-0 piperonal 
• 1484-85-1 3,4-methylenedioxyphenylethylamine 
• 1485-00-3 5-(2-nitrovinyl)benzo[1,3]dioxole 
• 3897-89-0 4-(hydroxymethyl)benzene-1,2-diol 
• 25379-88-8 2-(3,4-dihydroxyphenyl)acetic acid methyl ester 
• 131692-73-4 (2,2-Dimethyl-benzo[1,3]dioxol-5-yl)-[2-((S)-1-phenyl-ethylcarbamoyl)-benzoylaminooxy]-acetic acid 
• 131692-70-1 <aminocarbonyl>benzoic acid 

Relevant articles and documents

A method of synthesis of piperonolamine

The present invention belongs to the field of organic chemical synthesis, specifically relates to a synthesis method of piperine, comprising: using catechol as a raw material to prepare piperonaldehyde; β - nitro-3,4-dioxenosylstyrene prepared with piperonaldehyde; β - nitro -3,4-dioxenesimethylenestyrene to obtain piperine ethylamine. Among them, the preparation of piperaldehyde from catechol as raw materials includes two ways: (1) catechol→3,4-dihydroxymandelic acid→3,4-dihydroxybenzaldehyde→ piperaldehyde; (2) catechol→ piperine ring → piperine. The raw materials used in the present invention are safe and readily available, low cost; the reaction conditions are mild, the operation is simple, the chemical yield is high, and the intermediate reagents are easy to recover; suitable for industrial production.

PROCESS FOR STRAIGHTENING KERATIN FIBRES WITH A HEATING MEANS AND DENATURING AGENTS

The invention relates to a process for straightening keratin fibres, comprising: (i) a step in which a straightening composition containing at least two denaturing agents is applied to the keratin fibres, (ii) a step in which the temperature of the keratin fibres is raised, using a heating means, to a temperature of between 110 and 250° C.

Methyltrioxorhenium: A new catalyst for the activation of hydrogen peroxide to the oxidation of lignin and lignin model compounds

The oxidative degradation of lignin under totally chlorine free conditions is one of the most relevant targets for the design of environmental friendly pulping and bleaching industrial processes. Methyltrioxorhenium was found a powerful and promising catalyst for the oxidation of both phenolic and non-phenolic lignin model compounds by use of hydrogen peroxide as primary oxidant. Three different technical lignins, hydrolytic sugar cane lignin (SCL), red spruce kraft lignin (RSL) and a hardwood organosolvent lignin (OSL), that are representative examples of widely diffused para-hydroxyphenyl-guaiacyl, guaiacyl and guaiacyl-syringyl lignins, were also extensively degraded under similar experimental conditions.