77502-74-0Relevant academic research and scientific papers
Synthesis, electrochemical and anti-microbial study of 2,5-diamino benzoquinones
Asha,Suma
, (2021/12/29)
Fifteen symmetric and unsymmetric 2,5-diamino benzoquinones have been synthesized and their electrochemical activity was studied by cyclic voltammetry. Presence of electron donating substituent like amino group found to shift the half wave potential towar
Development of quinone analogues as dynamin GTPase inhibitors
Macgregor, Kylie A.,Abdel-Hamid, Mohammed K.,Odell, Luke R.,Chau, Ngoc,Whiting, Ainslie,Robinson, Phillip J.,McCluskey, Adam
, p. 191 - 206 (2014/08/18)
Virtual screening of the ChemDiversity and ChemBridge compound databases against dynamin I (dynI) GTPase activity identified 2,5-bis-(benzylamino)-1,4- benzoquinone 1 as a 273 ± 106 μM inhibitor. In silico lead optimization and focused library-led synthesis resulted in the development of four discrete benzoquinone/naphthoquinone based compound libraries comprising 54 compounds in total. Sixteen analogues were more potent than lead 1, with 2,5-bis-(4-hydroxyanilino)-1,4-benzoquinone (45) and 2,5-bis(4-carboxyanilino)- 1,4-benzoquinone (49) the most active with IC50 values of 11.1 ± 3.6 and 10.6 ± 1.6 μM respectively. Molecular modelling suggested a number of hydrogen bonding and hydrophobic interactions were involved in stabilization of 49 within the dynI GTP binding site. Six of the most active inhibitors were evaluated for potential inhibition of clathrin-mediated endocytosis (CME). Quinone 45 was the most effective CME inhibitor with an IC50(CME) of 36 ± 16 μM.
MECANISMES DE REDUCTION ELECTROCHIMIQUE DES QUINONES MONO ET DICHLORIMINE SUR PLATINE. ETUDE ET STRUCTURE DES COMPOSES OBTENUS LORS DE COULOMETRIES A FORTE CONCENTRATION
Bonastre, J.,Castetbon, A.,Andrieu, X.
, p. 145 - 152 (2007/10/02)
In this work, electrochemical reduction of quinone mono and dichlorimine was investigated on platinum cathodes.The first product produces paraaminophenol and the second produces paraphenylenediamine.Chemical reactions occur when the concentration of initial product is higher than E-4 M.Reaction between quinone monochlorimine and its ultimate reduction product occurs when concentrated solution are electrolysed on a platinum cathode.In this work, the nature and the structure of the reaction products were eluciated by physicochemical methods.An approach of the reaction mechanism is proposed.
