77513-40-7Relevant academic research and scientific papers
A simple and effective synthesis of 3- And 4-((Phenylcarbamoyl)oxy)benzoic acids
Gobec, Stanislav,Ko?ak, Urban
, p. 940 - 948 (2020/10/02)
Phenserine, posiphen, tolserine and cymserine and its derivatives are experimental Alzheimer's disease drugs that contain a phenyl phenylcarbamate moiety that is responsible for their anti-Alzheimer activities. We have developed a simple (3 steps) and effective (overall yields 76-90%) method for preparing 3- and 4-((phenylcarbamoyl)oxy)benzoic acids which can be reacted with amines to produce phenyl phenylcarbamate moiety containing amides as new potential anti-Alzheimer disease drugs. The synthesized carboxylic acids are thus important building blocks with potential use in medicinal chemistry and drug discovery.
Phosphonate-based irreversible inhibitors of human γ-glutamyl transpeptidase (GGT). GGsTop is a non-toxic and highly selective inhibitor with critical electrostatic interaction with an active-site residue Lys562 for enhanced inhibitory activity
Kamiyama, Akane,Nakajima, Mado,Han, Liyou,Wada, Kei,Mizutani, Masaharu,Tabuchi, Yukiko,Kojima-Yuasa, Akiko,Matsui-Yuasa, Isao,Suzuki, Hideyuki,Fukuyama, Keiichi,Watanabe, Bunta,Hiratake, Jun
supporting information, p. 5340 - 5352 (2016/10/24)
γ-Glutamyl transpeptidase (GGT, EC 2.3.2.2) that catalyzes the hydrolysis and transpeptidation of glutathione and its S-conjugates is involved in a number of physiological and pathological processes through glutathione metabolism and is an attractive phar
NOVEL COMPOUNDS AND THEIR USE IN THERAPY
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Page/Page column 73-74, (2013/06/27)
The invention provides compounds which inhibit N-myristoyltransferase and are selective for protozoal N-myristoyltransferase and, consequently suitable to treat microbial infections, including viral and fungal infections, and protozoan infections such as malaria, leishmaniasis and sleeping sickness.
Chemoselective esterification of phenolic acids in the presence of sodium bicarbonate in ionic liquids
Ambika,Singh, Pradeep Pratap,Chauhan
, p. 928 - 936 (2008/09/17)
Chemoselective esterification of phenolic acids with dialkyl sulphates or alkyl halides in the presence of sodium bicarbonate in 1,3-dialkylimidazolium ionic liquids is reported in excellent yields and less reaction time as compared to organic solvents. Copyright Taylor & Francis Group, LLC.
Process for the preparation of carboxylic benzyl esters
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, (2008/06/13)
Carboxylic benzyl esters can be prepared by reacting benzyl chloride with carboxylic acids in the presence of one or more quaternary ammonium carboxylates as catalyst.
Formal total synthesis of the PKC inhibitor, balanol: Preparation of the fully protected benzophenone fragment
Laursen, Bolette,Denieul, Marie-Pierre,Skrydstrup, Troels
, p. 2231 - 2238 (2007/10/03)
The synthesis of a perbenzylated derivative of balanol's highly functionalized benzophenone fragment is reported employing a regioselective Heck reaction as the key step for the connection of the two aromatic rings. The intermediate 7-membered lactone obt
ANTITHROMOBOTIC AGENTS
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, (2008/06/13)
This invention relates to L-arginine aldehyde derivatives, having the Formula I STR1 where X and Y have the values defined in the description, as well as pharmaceutical formulations containing those compounds and methods of their use as thrombin inhibitors, coagulation inhibitors, and thromboembolic disorder agents.
