77517-29-4

Basic information

• Product Name: dihydromevinolin
• Synonyms: dihydromevinolin;(S)-2-Methylbutyric acid [(1S)-1,2,3,4,4a,7,8,8aα-octahydro-3β,7α-dimethyl-8α-[2-[[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran]-2-yl]ethyl]naphthalen]-1β-yl ester;dihydro-lovastatin;Lovastatin Related CoMpound A;Lovastatin Related Compound A (20 mg) (Dihydro-lovastatin);(2S)-2-Methylbutanoic Acid (1S,3S,4aR,7S,8S,8aS)-1,2,3,4,4a,7,8,8a-Octahydro- 3,7-diMethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl Ester;4a,5-Dihydro Lovastatin;L 154883
• CAS NO: 77517-29-4
• Molecular Formula: C24H38O5
• Molecular Weight: 406.55552
• Product Categories: Chiral Reagents;Heterocycles;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 77517-29-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 534.8°C at 760 mmHg
• Flash Point: 174.5°C
• Appearance: /
• Density: 1.1g/cm³
• Vapor Pressure: 1.14E-13mmHg at 25°C
• Refractive Index: 1.52
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• Solubility: Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly)
• PKA: 13.49±0.40(Predicted)
• CAS DataBase Reference: dihydromevinolin(CAS DataBase Reference)
• NIST Chemistry Reference: dihydromevinolin(77517-29-4)
• EPA Substance Registry System: dihydromevinolin(77517-29-4)

Safety Data

• Hazardous Substances Data: 77517-29-4(Hazardous Substances Data)

Usage

Chemical Properties

White to Off-White Solid

Uses

Different sources of media describe the Uses of 77517-29-4 differently. You can refer to the following data:
1. 4a,5-Dihydro Lovastatin (Lovastatin EP Impurity E; Lovastatin USP Related Compound A) is an impurity in Lovastatin (L472225) bulk drug.
2. 4a,5-Dihydro Lovastatin is an impurity in Lovastatin (L472225) bulk drug.

InChI:InChI=1/C24H38O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,14-21,23,25H,5,8-13H2,1-4H3/t14-,15-,16-,17-,18+,19+,20-,21-,23+/m0/s1

Upstream product

• 84131-91-9 (S)-(+)-2-methylbutyric anhydride 
• 79902-31-1 (4R,6R)-6-[2-((1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthyl)ethyl]-4-[(tert-butyldimethylsilyl)oxy]-3,4,5,6-tetrahydro-2H-pyran-2-one 
• 129264-88-6 (1S,2S,4aR,6S,8S,8aS)-1-<2-<3(R)-<4(R)-<oxy>-1(S)-hydroxy-3-cyclopentyl>>ethyl>-2,6-dimethyl-8-<<(S)-2-methyl-1-oxobutyl>oxy>-1,2,4a,5,6,7,8,8a-octahydronaphthalene 
• 129264-88-6 (1S,2S,4aR,6S,8S,8aS)-1-<2-<3(R)-<4(R)-<oxy>-1(R)-hydroxy-3-cyclopentyl>>ethyl>-2,6-dimethyl-8-<<(S)-2-methyl-1-oxobutyl>oxy>-1,2,4a,5,6,7,8,8a-octahydronaphthalene 
• 129264-81-9 (1S,2S,4aR,6S,8S,8aS)-8-<(tert-butyldimethylsilyl)oxy>-2,6-dimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carboxaldehyde 
• 129264-80-8 (1R,2S,4aR,6S,8S,8aS)-8-<(tert-butyldimethylsilyl)oxy>-2,6-dimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carboxaldehyde 
• 129264-79-5 (1R,2S,4aR,6S,8S,8aS)-8-<(tert-butyldimethylsilyl)oxy>-2,6-dimethyl-1-(hydroxymethyl)-1,2,4a,5,6,7,8,8a-octahydronaphthalene 
• 129313-10-6 (1R,2S,4aR,6S,8S,8aS)-2,6-dimethyl-1-(hydroxymethyl)-8-hydroxy-1,2,4a,5,6,7,8,8a-octahydronaphthalene 
• 129264-89-7 (1S,2S,4aR,6S,8S,8aS)-1-<2-<2-<1(R)-<oxy>-4(R)-(benzyloxy)cyclopentyl>>ethyl>-2,6-dimethyl-8-<<(S)-2-methyl-1-oxobutyl>oxy>-1,2,4a,5,6,7,8,8a-octahydronaphthalene 
• 109000-29-5 (3R,5S)-dimethyl-<6-<(tert-butyldiphenylsilyl)oxy>-3-methyl-2-oxo-5-(trimethylsiloxy)hexyl>phosphonate 
• 129264-86-4 (1S,2S,4aR,6S,8S,8aS)-1-<2-nitro-2-<3(S)-<4(R)-<oxy>-1-oxo-3-cyclopentyl>>ethyl>-2,6-dimethyl-8-<<(S)-2-methylbutyryl>oxy>-1,2,4a,5,6,7,8,8a-octahydronaphthalene 
• 129264-70-6 (2S,4R,5S,6E,8E)-1-<(tert-butyldiphenylsilyl)oxy>-5-(methoxymethoxy)-4-methyl-2-<(trimethylsilyl)oxy>-6,8-decadiene 
• 129264-72-8 (2S,4R,5S,6E,8E)-1-<<(2',4',6'-triisopropylphenyl)-sulfonyl>oxy>-5-(methoxymethoxy)-4-methyl-6,8-decadien-2-ol 
• 129264-91-1 (1S,2S,4aR,6S,8S,8aS)-1-<2-<2(R)-<4(R)-(benzyloxy)-1-oxocyclopentyl>>ethyl>-2,6-dimethyl-8-<<(S)-2-methyl-1-oxobutyl>oxy>-1,2,4a,5,6,7,8,8a-octahydronaphthalene 

Relevant articles and documents

Synthesis of (+)-Dihydromevinolin by Selective Reduction of Mevinolin

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Total Synthesis of (+)-Dihydromevinolin

A total syntheses of (+)-dihydromevinolin (2b) is presented, as well as the preparation of three analogues (62, 63, and 64) for assessment of their biological activity.Base-promoted fragmentation of the tosylhydrazone (20) of key intermediate 6 affords ac

Reductive Transformation and Cyclopropanation of Mevinolin (α-Methylcompactin). Generation of Chirality in the 1,4-Hydrostannation of a Cyclic Diene

Conversion of mevinolin by direct reductive procedures as well as by indirect chemical transformations has permitted the preparation of the various di- and tetrahydro derivatives.Cyclopropanation of mevinolin and its derivatives has furnished mono- and di