7752-72-9

Usage

Uses

Used in Pharmaceutical Industry:
5-CHLORO-6-METHYLPYRIMIDIN-4(1H)-ONE is used as an intermediate in the synthesis of pharmaceuticals for its potential to contribute to the development of new drugs. Its unique chemical structure allows it to be a key component in the creation of molecules with specific therapeutic properties, enhancing the range of treatments available for various medical conditions.
Used in Agrochemical Industry:
In the agrochemical sector, 5-CHLORO-6-METHYLPYRIMIDIN-4(1H)-ONE is utilized as a precursor in the production of agrochemicals. Its reactivity and structural features make it suitable for the synthesis of compounds that can be used in pest control, crop protection, and other agricultural applications, thereby contributing to increased crop yields and more effective management of pests and diseases.
Used as a Building Block in Organic Synthesis:
5-CHLORO-6-METHYLPYRIMIDIN-4(1H)-ONE is employed as a building block in the synthesis of various organic compounds due to its reactive sites and structural attributes. This allows chemists to create a wide array of molecules with different functionalities and applications, expanding the scope of chemical research and development across multiple industries.

InChI:InChI=1/C5H5ClN2O/c1-3-4(6)5(9)8-2-7-3/h2H,1H3,(H,7,8,9)

Upstream product

• 6313-33-3 formamidine hydrochloride 
• 609-15-4 ethyl 2-chloro-3-oxo-butyrate 
• 463-52-5 formamidine 
• 3473-63-0 formamidine acetic acid 
• 3524-87-6 6-methyl-3H-pyrimidin-4-one 
• 6710-83-4 formimidamide acetate 

Downstream Products

• 83942-10-3 4,5-dichloro-6-methyl-pyrimidine 
• 792909-14-9 5-chloro-6-(chloromethyl)-3H-pyrimidin-4-one 

Relevant academic research and scientific papers

SUBSTITUTED PYRIMIDINE COMPOUND AND PREPARATION METHOD AND USE THEREOF

The present invention discloses a substituted pyrimidine compound. The structure is shown in general formula I. The definition of each substituent in the formula is described in the description. The compound of the present invention has broad-spectrum fungicidal, insecticidal and acaricidal activity, and has excellent control effects on cucumber downy mildew, powdery mildew, corn rust, anthrax, rice blast, aphids, Tetranychus cinnabarinus and the like.

Preparation and application of substituted pyrazole compound containing pyriminostrobin

The invention discloses a substituted pyrazole compound containing pyrimidine amine as shown in a general formula I. The definition of each substituent in the formula is described in the description. The compounds of the invention have a broad spectrum of sterilization. The insecticidal acaricidal activity has an excellent control effect on cucumber downy mildew, wheat powdery mildew, corn rust, rice blast, cucumber anthracnose and the like. The compounds of the invention exhibit good insecticidal activity at the same time.

Spirocyclic compound containing pyrimidine and application thereof

The invention discloses a pyrimidine-containing spiro compound, structure as shown in a general formula I : The compound of the invention has a broad-spectrum bactericidal activity . and has an excellent control effect, on cucumber downy mildew, wheat powdery mildew, corn rust, rice blast, cucumber anthracnose and the like.

Piperidine-containing pyrimidine compound and application thereof

The invention belongs to the field of agricultural bactericidal, insecticidal and acaricidal agents, and particularly relates to a novel piperidine-containing pyrimidine compound and application thereof. The structure of the piperidine-containing pyrimidine compound is shown as a general formula I, wherein the definition of each substituent group in the formula is shown in the specification. The compound provided by the invention has broad-spectrum bactericidal, insecticidal and acaricidal activity, has excellent prevention and treatment effects on cucumber downy mildew, corn rust, wheat powdery mildew, rice blast and anthracnose, and especially has better prevention and treatment effects on cucumber downy mildew and corn rust, and also has excellent prevention and treatment effects on plutella xylostella, aphid, tetranychus cinnabarinus and the like. And a very good effect can be obtained under a very low dosage. The compound provided by the invention also has the characteristics of simple preparation method and the like.

Design, synthesis, insecticidal, and acaricidal activities of novel pyrimidinamine derivatives containing a biphenyl ether

A series of original pyrimidinamine derivatives containing a biphenyl ether moiety were designed and synthesized. Their structures were confirmed by 1H NMR, MS, and elemental analyses. Their insecticidal activities against lepidopteran and hemiptera insects and acaricidal activities were tested. The results of bioassay demonstrated that 9k showed the best activity (LC50 = 2.08 mg/L) against Tetranychus urticae, which is comparable with the positive control, spirotetramat (LC50 = 2.27 mg/L), and 9g showed better activity (LC50 = 0.52 mg/L) against Aphis fabae than the positive control, imidacloprid (LC50 = 1.02 mg/L), and relatively good activity (LC50 = 2.49 mg/L) against T urticae. Their structure-activity relationships indicated that both an ethyl group on the 4-position of the pyrimidine ring and alkyl chain as a para-substituent group of the benzene ring showed good biological activity.

Substituted pyrimidine compound and use thereof (by machine translation)

The invention discloses a broad-spectrum bactericidal killing activity of substituted pyrimidine compound, structure such as formula (I) as shown: In the type of each substituent is as defined in the specification. The compounds of this invention have broad-spectrum sterilization insecticidal or acaricidal activity, the cucumber downy mildew, corn rust, wheat powdery mildew, rice blast, cucumber gray mold disease such as has fine control effects, in particular to the cucumber downy mildew, corn rust, such as rice blast control effect better; Diamondback moth, sticky, aphid and preparing fuel also have fine control effects, at a very low dosage can be obtained very good results. (by machine translation)

Substituted pyrazole compound containing pyrimidine, and preparation method and use thereof

The invention discloses a substituted pyrazole compound containing pyrimidine, wherein the compound has a structure represented by the general formula I, and the definitions of substituents in the formula are defined in the specification. The compound has broad-spectrum bactericidal activity, and has excellent prevention and treatment effects on cucumber downy mildew, corn rust disease, rice blastand the like.

Substituted Pyrazole Compounds Containing Pyrimidine and Preparation Method and Use Thereof

Disclosed are substituted pyrazole compounds containing pyrimidinyl as shown in Formula I: The definitions of each of the substituents can be seen in the description. The compounds of present invention have a good spectrum of bactericidal, insecticidal and acaricidal activity,and have good control effect on downy mildew of cucumber, powdery mildew of wheat, corn rust, rice blast, cucumber anthracnosis and the like. The compounds of present invention also show good insecticidal activity.

Pyrimidine-containing substituted azole compounds and application thereof

The invention discloses pyrimidine-containing substituted azole compounds with a structure as shown in a formula 1 in the description. In the formula 1, the definition of each substituent is enclosedin the description. The compounds disclosed by the invention have broad-spectrum bactericidal function and insecticidal and acaricidal activities, and have excellent control efficacy on cucumber downymildew, puccinia polysora, cucumber anthracnose and the like, in particular on cucumber downy mildew and puccinia polysora. Part of the compounds show certain insecticidal cavity on myzus persicae and tetranychus cinnabarinus at the same time. The pyrimidine-containing substituted azole compounds can be used for preparing bactericidal, insecticidal and acaricidal agents.

Design, synthesis and antifungal activity of new substituted difluoromethylpyrimidinamine derivatives

Rusts are one of the most important fungal diseases, the known target sites have already developed serious resistance to the main existing classifications of fungicides. In order to discover novel fungicides with a promising activity on rusts, twenty new substituted difluoromethylpyrimidinamine derivatives were designed and synthesized with the aid of the intermediate derivatization methods starting from ethyl 4,4-difluoro-3-oxobutanoate that is the common raw material in some newly launched important succinate dehydrogenase inhibitor (SDHI) fungicides. Their structures were identified by 1H NMR, 13C NMR, 19F NMR, IR, elemental analyses and HRMS. All the compounds were screened for in vivo fungicidal activity against southern corn rust (SCR). The preliminary bioassay results indicated that 5-chloro-6-(difluoromethyl)-N-(2-(6-(3-(trifluoromethyl)phenoxy)pyridin-3-yl)ethyl)pyrimidin-4-amine (compound J, R1 = CHF2, Alk = CH2CH2, Rn = 3-CF3) is the optimal structure with desired fungicidal activity against SCR (EC50 = 2.16 mg/L), significantly higher than commercial fungicides diflumetorim (EC50 = 53.26 mg/L) and propiconazole (EC50 = 3.92 mg/L). The structure–activity relationship of the synthesized compounds was discussed as well. This study also demonstrated that difluoromethylpyrimidinamine derivatives can be further utilized as a promising antifungal agent to control rust. Further synthesis and structure optimization studies are currently in progress.