7752-74-1

Usage

Uses

Used in Pharmaceutical Research and Development:
5-IODO-6-METHYLPYRIMIDIN-4-OL is used as a building block for the synthesis of various pharmaceutical products, contributing to the development of new medications and therapies.
Used in Agrochemical Production:
In the agrochemical industry, 5-IODO-6-METHYLPYRIMIDIN-4-OL is utilized as an intermediate, playing a crucial role in the production of crop protection agents and other agricultural chemicals.
Used in Specialty Chemicals Manufacturing:
5-IODO-6-METHYLPYRIMIDIN-4-OL is employed as a versatile building block in the synthesis of a wide range of specialty chemicals, catering to diverse industrial needs.
Used in Medicinal Chemistry and Drug Discovery:
Possessing potential applications in medicinal chemistry, 5-IODO-6-METHYLPYRIMIDIN-4-OL is used for the exploration and development of biologically active compounds, which may lead to the discovery of new drugs and therapeutic agents.

Upstream product

• 3524-87-6 4-hydroxy-6-methylpyrimidine 
• 56-04-2 6-methyl-2-thiouracil 
• 3524-87-6 6-methyl-3H-pyrimidin-4-one 

Downstream Products

• 83410-15-5 4-chloro-5-iodo-6-methyl-pyrimidine 
• 1436405-29-6 N-(3-(-2-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-6-methylpyrimidin-5-yl)vinyl)phenyl)-4-(dimethylamino)but-2-enamide 
• 912354-47-3 N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-5-iodo-6-methylpyrimidin-4-amine 
• 1436405-28-5 N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-methyl-5-vinylpyrimidin-4-amine 
• 1436405-30-9 N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-methyl-5-(2-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)furan-2-yl)vinyl)pyrimidin-4-amine 
• 912353-90-3 N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-methyl-5-((5-(((2-(methylsulfonyl)ethyl)amino)methyl)furan-2-yl)ethynyl)pyrimidin-4-amine 
• 1436405-31-0 N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-5-ethynyl-6-methylpyrimidin-4-amine 
• 1436405-33-2 4-(3-chloro-4-(pyridin-2-ylmethoxy)phenoxy)-5-iodo-6-methylpyrimidine 
• 1436405-34-3 4-(3-chloro-4-(pyridin-2-ylmethoxy)phenoxy)-5-ethynyl-6-methylpyrimidine 
• 1436405-35-4 N-((5-((4-(3-chloro-4-(pyridin-2-ylmethoxy)phenoxy)-6-methylpyrimidin-5-yl)ethynyl)furan-2-yl)methyl)-2-(methylsulfonyl)ethanamine 
• 83410-18-8 4-Amino-5-iod-6-methyl-pyrimidin 
• 912353-72-1 C₂₇H₂₈ClFN₄O₂ 
• 912353-86-7 C₃₁H₂₈ClFN₄O₂ 
• 912353-71-0 C₂₆H₂₆ClFN₄O₂ 

Relevant academic research and scientific papers

Design, synthesis and biological evaluation of novel pyrimidine, 3-cyanopyridine and m-amino-N-phenylbenzamide based monocyclic EGFR tyrosine kinase inhibitors

36 new compounds with the typical skeleton of 4-anilino-5-vinyl/ethynyl pyrimidine, 4-anilino-3-cyano-5-vinyl/ethynyl/phenyl pyridine, and m-amino-N-phenylbenzamide, are designed, synthesized and selectively tested on EGFR, ErbB-2 kinases, and A-549, HL60 cells growth inhibition. Results from the bioactivity and chemical structures yield preliminary structure-activity relationships (SARs). The most potent 5-ethynylpyrimidine derivative 20a has an IC50 value of 45 nM to EGFR kinase. Several compounds of other series also show IC50 values 1 μM for EGFR and 5 μM for A-549 and HL60 cells growth inhibition.

5-Alkynyl-pyridines

This invention relates to 5-alkynyl-pyridine of general formula (I) their use as inhibitors of the activity of PI3Kalpha, pharmaceutical compositions containing them, and their use as a medicaments for the treatment and/or prevention of diseases characterized by excessive or abnormal cell proliferation and associated conditions such as cancer. The groups R1 to R6 and n have the meanings given in the claims and in the specification

NEW 5-ALKYNYL-PYRIDINES

5-alkynyl-pyridine of general formula (I) which are inhibitors of the activity of PI3K alpha, and their use in the treatment of diseases characterized by excessive or abnormal cell proliferation, such as cancer.

5-ALKYNYL-PYRIMIDINES

The present invention encompasses compounds of general formula (1) wherein R1 to R4 R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.

NEW 5-ALKYNYL-PYRIDINES

This invention relates to 5-alkynyl-pyridine of general formula (I) their use as inhibitors of the activity of PI3Kalpha, pharmaceutical compositions containing them, and their use as a medicaments for the treatment and/or prevention of diseases characterized by excessive or abnormal cell proliferation and associated conditions such as cancer. The groups R1 to R6 and n have the meanings given in the claims and in the specification.

NEW 5-ALKYNYL-PYRIDINES

This invention relates to 5-alkynyl-pyridine of general formula (I) their use as inhibitors of the activity of P13Kalpha, pharmaceutical compositions containing them, and their use as a medicaments for the treatment and/or prevention of diseases characterized by excessive or abnormal cell proliferation and associated conditions such as cancer. The groups R1 to R6 and n have the meanings given in the claims and in the specification.

5-ALKYNYL PYRIMIDINES AND THEIR USE AS KINASE INHIBITORS

The present invention encompasses compounds of general formula (1) wherein R1 to R4 R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.

Synthesis and evaluation of novel pyrimidine-based dual EGFR/Her-2 inhibitors

A structure-activity relationship study of 4-anilinopyrimidines for dual EGFR/Her-2 inhibitor has resulted in the identification of 4-anilino-5-alkenyl or 5-alkynyl-6-methylpyrimidine derivatives that have exhibited effective inhibitory activity against both enzymes. The presence of 5-alkenyl or 5-alkynyl moiety bearing terminal hydrophilic group played important role for inhibition of these enzymes. Selected compounds in the series demonstrated some activity against Her-2 dependent cell line (BT474).