83410-15-5

Basic information

• Product Name: 4-CHLORO-5-IODO-6-METHYLPYRIMIDINE
• Synonyms: 4-CHLORO-5-IODO-6-METHYLPYRIMIDINE
• CAS NO: 83410-15-5
• Molecular Formula: C₅H₄ClIN₂
• Molecular Weight: 254.46
• Mol File: 83410-15-5.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• Storage Temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
• CAS DataBase Reference: 4-CHLORO-5-IODO-6-METHYLPYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-5-IODO-6-METHYLPYRIMIDINE(83410-15-5)
• EPA Substance Registry System: 4-CHLORO-5-IODO-6-METHYLPYRIMIDINE(83410-15-5)

Safety Data

• Hazardous Substances Data: 83410-15-5(Hazardous Substances Data)

Usage

General Description

4-CHLORO-5-IODO-6-METHYLPYRIMIDINE is a chemical compound with the molecular formula C6H5ClIN2. It is a pyrimidine derivative with chlorine and iodine substituents at the 4 and 5 positions, respectively, and a methyl group at the 6 position. 4-CHLORO-5-IODO-6-METHYLPYRIMIDINE is a versatile building block in organic synthesis and pharmaceutical research, often used as a precursor in the production of various pharmaceuticals and agrochemicals. Its unique structure and reactivity make it valuable in the development of novel compounds with potential pharmacological and biological activities. Due to its potential applications in medicine and agriculture, 4-CHLORO-5-IODO-6-METHYLPYRIMIDINE is of significant interest to researchers and industries in the chemical and pharmaceutical sectors.

Upstream product

• 7752-74-1 4-hydroxy-5-iodo-6-methylpyrimidine 
• 56-04-2 6-methyl-2-thiouracil 
• 3524-87-6 4-hydroxy-6-methylpyrimidine 
• 3524-87-6 6-methyl-3H-pyrimidin-4-one 
• 7752-74-1 5-iodo-6-methyl-3H-pyrimidin-4-one 

Downstream Products

• 912353-72-1 C₂₇H₂₈ClFN₄O₂ 
• 912353-86-7 C₃₁H₂₈ClFN₄O₂ 
• 912353-71-0 C₂₆H₂₆ClFN₄O₂ 
• 912354-03-1 C₂₅H₂₄ClFN₄O₂ 
• 912354-05-3 C₂₇H₂₇ClFN₅O₃ 
• 912353-73-2 C₂₇H₂₈ClFN₄O 
• 912353-74-3 C₂₉H₃₃ClFN₅O 
• 912353-78-7 C₂₉H₂₆ClFN₄O 
• 912354-47-3 N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-5-iodo-6-methylpyrimidin-4-amine 
• 1391978-02-1 2-bromo-N-[2-methyl-5-(4-methyl-6-morpholin-4-ylpyrimidin-5-ylethynyl)-pyridin-3-yl]-benzenesulfonamide 
• 1391978-01-0 2,6-difluoro-N-[2-methyl-5-(4-methyl-6-morpholin-4-yl-pyrimidin-5-ylethynyl)-pyridin-3-yl]-benzenesulfonamide 
• 1391978-00-9 3-fluoro-N-[2-methyl-5-(4-methyl-6-morpholin-4-yl-pyrimidin-5-ylethynyl)-pyridin-3-yl]-benzenesulfonamide 
• 1391977-99-3 2-chloro-N-[2-methyl-5-(4-methyl-6-morpholin-4-ylpyrimidin-5-ylethynyl)-pyridin-3-yl]-benzenesulfonamide 
• 1391977-98-2 3-methoxy-N-[2-methyl-5-(4-methyl-6-morpholin-4-ylpyrimidin-5-ylethynyl)-pyridin-3-yl]-benzenesulfonamide 

Relevant articles and documents

Hetero-aromatic compound and its use in medicine

The invention provides a hetero-aromatic compound or a stereisomer, geometric isomer, tautomer, despinner, nitrogen oxide, hydrate, solvate, metabolite, metabolism precursor and pharmaceutically acceptable salt or prodrug thereof, which is used for treating proliferative diseases. The invention also discloses a pharmaceutical composition containing the compound and an application of the compound or pharmaceutical composition thereof in preparation of a medicine for treating proliferative diseases.

NEW 5-ALKYNYL-PYRIDINES

5-alkynyl-pyridine of general formula (I) which are inhibitors of the activity of PI3K alpha, and their use in the treatment of diseases characterized by excessive or abnormal cell proliferation, such as cancer.

NEW 5-ALKYNYL-PYRIDINES

This invention relates to 5-alkynyl-pyridine of general formula (I) their use as inhibitors of the activity of PI3Kalpha, pharmaceutical compositions containing them, and their use as a medicaments for the treatment and/or prevention of diseases characterized by excessive or abnormal cell proliferation and associated conditions such as cancer. The groups R1 to R6 and n have the meanings given in the claims and in the specification.