77530-34-8Relevant academic research and scientific papers
Intramolecular cyclopropanation reactions en route to novel P- heterocycles
Hanson, Paul R.,Sprott, Kevin T.,Wrobleski, Aaron D.
, p. 1455 - 1458 (2007/10/03)
The first examples of intramolecular cyclopropanation reactions on a phosphonate template catalyzed by Rh2(OAc)4 are described. These reactions proceed in excellent yield and give mixtures of the P-heterocycles cis-2a-d and trans-2a-d with moderate levels of diastereoselectivity. The diastereoselectivity of this transformation is dependent upon the size of the alkyl group R contained in the alkyl α-diazodiallylphosphonoacetate starting materials 1a-d.
Synthesis of Analogues of 5-Iodo-2'-deoxyuridine-5'-diphosphate
Jennings, L. John,Macchia, Marco,Parkin, Ann
, p. 2197 - 2202 (2007/10/02)
The synthesis of three types of diphosphate analogues of 5-iodo-2'-deoxyuridine-5'-diphosphate is reported.Routes are described to the 5'-phosphonoacetamido, the 5'-N-phosphonosulfamoyl and the 5'-O-sulfamoylcarbamoyl derivatives, 2, 3 and 4 starting from
Carboxylic esters of phosphonoacetic acid
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, (2008/06/13)
A method of treating herpes simplex infections in warm-blooded animals by administering to said animals a carboxylic ester of phosphonoacetic acid of the formula STR1 wherein R is a C3 -C8 alkyl, aralkyl, STR2 ADAMANTYL, OR GLYCERYL ESTERS OF THE FORMULA STR3 where R' is an alkyl of 2-20 carbon atoms, or its inorganic salts.
