775354-32-0Relevant academic research and scientific papers
Discovering Novel α-aminoacyl-Containing Proline Derivatives with Potent and Selective Inhibitory Activity Against Dipeptidyl Peptidase IV: Design, Synthesis, Biological Evaluation, and Molecular Modeling
Zhang, Xiaodong,Wang, Jiang,Li, Zeng,Liu, Hong,Su, Mingbo,Li, Jingya,Li, Jia
, p. 843 - 852,10 (2012/12/12)
On the basis of the enzyme-binding features of known potent inhibitors of dipeptidyl peptidase IV, novel α-aminoacyl-containing proline analogs (8Aa-8Ak, 8Ba-8Bj, 8Ca-8Ck, and 8Da-8Di) with the S configuration were designed, synthesized, and their activit
Potent and selective proline derived dipeptidyl peptidase IV inhibitors
Edmondson, Scott D.,Mastracchio, Anthony,Beconi, Maria,Colwell Jr., Lawrence F.,Habulihaz, Bahanu,He, Huaibing,Kumar, Sanjeev,Leiting, Barbara,Lyons, Kathryn A.,Mao, Ann,Marsilio, Frank,Patel, Reshma A.,Wu, Joseph K.,Zhu, Lan,Thornberry, Nancy A.,Weber, Ann E.,Parmee, Emma R.
, p. 5151 - 5155 (2007/10/03)
In-house screening of the Merck sample collection identified proline derived homophenylalanine 3 as a DPP-IV inhibitor with modest potency (DPP-IV IC50 = 1.9 μM). Optimization of 3 led to compound 37, which is among the most potent and selectiv
