775356-24-6

Basic information

• Product Name: 4-(2-isopropyl-5-methyl-cyclohexyloxymethyl)-phenol
• Synonyms: 4-(2-isopropyl-5-methyl-cyclohexyloxymethyl)-phenol
• CAS NO: 775356-24-6
• Molecular Weight: 262.392
• Mol File: 775356-24-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4-(2-isopropyl-5-methyl-cyclohexyloxymethyl)-phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-isopropyl-5-methyl-cyclohexyloxymethyl)-phenol(775356-24-6)
• EPA Substance Registry System: 4-(2-isopropyl-5-methyl-cyclohexyloxymethyl)-phenol(775356-24-6)

Safety Data

• Hazardous Substances Data: 775356-24-6(Hazardous Substances Data)

Upstream product

• 150766-59-9 1-bromo-4-((((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)oxy)methyl)benzene 
• 853654-19-0 1-[4-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-1-methyl-siletane 
• 853654-21-4 1-(4-bromomethyl-phenyl)-1-methyl-siletane 
• 853654-20-3 [4-(1-methyl-siletan-1-yl)-phenyl]-methanol 
• 107556-40-1 <4-<<(tert-butyldimethylsilyl)oxy>methyl>phenyl>magnesium bromide 
• 623-05-2 (4-hydroxyphenyl)methanol 
• 2216-51-5 (-)-menthol 

Downstream Products

• 548464-35-3 4-methoxybenzyl (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl ether 
• 150766-59-9 1-bromo-4-((((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)oxy)methyl)benzene 
• 2216-51-5 (-)-menthol 

Relevant articles and documents

Rapid heteroatom transfer to arylmetals utilizing multifunctional reagent scaffolds

Arylmetals are highly valuable carbon nucleophiles that are readily and inexpensively prepared from aryl halides or arenes and widely used on both laboratory and industrial scales to react directly with a wide range of electrophiles. Although C-C bond formation has been a staple of organic synthesis, the direct transfer of primary amino (-NH2) and hydroxyl (-OH) groups to arylmetals in a scalable and environmentally friendly fashion remains a formidable synthetic challenge because of the absence of suitable heteroatom-transfer reagents. Here, we demonstrate the use of bench-stable N-H and N-alkyl oxaziridines derived from readily available terpenoid scaffolds as efficient multifunctional reagents for the direct primary amination and hydroxylation of structurally diverse aryl- and heteroarylmetals. This practical and scalable method provides one-step synthetic access to primary anilines and phenols at low temperature and avoids the use of transition-metal catalysts, ligands and additives, nitrogen-protecting groups, excess reagents and harsh workup conditions.

The para-siletanylbenzyl (PSB) ether: A peroxide-cleavable protecting group for alcohols and phenols

A novel arylmethyl protecting group that is electronically similar to benzyl (Bn) but that can be cleaved under mild oxidizing conditions in the presence of para-methoxybenzyl (PMB) is described herein. para-Siletanylbenzyl (PSB) ethers are formed in one or two steps from the corresponding alcohols and cleaved in one or two steps with basic peroxide. Alcohols and phenols have been protected in good yields and deprotected cleanly under mild oxidative conditions.