39739-52-1

Upstream product

• 67-56-1 methanol 
• 619-72-7 4-nitrobenzonitrile 
• 79-20-9 acetic acid methyl ester 

Downstream Products

• 77570-26-4 5-[Amino-(4-nitro-phenyl)-methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione 
• 95649-23-3 3-[5-(4-Nitro-phenyl)-[1,2,4]oxadiazol-3-yl]-1H-indole 
• 25033-14-1 O-methyl 4-nitrobenzenecarbothioic acid 
• 95649-27-7 3-[5-(4-Nitro-phenyl)-[1,2,4]oxadiazol-3-ylmethyl]-1H-indole 
• 126336-35-4 1-(Dimethoxy-methylsulfanyl-methyl)-4-nitro-benzene 
• 77570-32-2 ethyl 3-amino-3-(4-nitrophenyl)-2-propenoate 
• 67095-86-7 N,N-dimethyl-4-nitrobenzamidine 
• 25412-75-3 4-nitrobenzamidine 
• 124595-98-8 5-chloro-2-(4-nitrophenyl)pyrimidine 
• 308846-66-4 methyl (S)-2-(4-nitrophenyl)-4,5-dihydrooxazole-4-carboxylate 
• 1181214-76-5 3-(4-nitrophenyl)-1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazole 

Relevant academic research and scientific papers

N-Phenyl-4,5-dibromopyrrolamides and N-Phenylindolamides as ATP Competitive DNA Gyrase B Inhibitors: Design, Synthesis, and Evaluation

Bacterial DNA gyrase is a well-known and validated target in the design of antibacterial drugs. However, inhibitors of its ATP binding subunit, DNA gyrase B (GyrB), have so far not reached clinical use. In the present study, three different series of N-ph

One-pot synthesis of 2,5-disubstituted pyrimidines from nitriles

A practical, one-step process for the synthesis of 2,5-disubstituted pyrimidines is presented. The protocol proved to be general for the synthesis of a variety of pyrimidine-containing compounds bearing an assortment of functional groups.

SULFONYL-AMIDINO CONTAINING AND TETRAHYDROPYRIMIDINO CONTAINING COMPOUNDS AS FACTOR XA INHIBITORS

The present application describes sulfonyl-amidino-containing and tetrahydropyrimidino-containing compounds and derivatives thereof of Formula (I): P4-P-M-M4 or pharmaceutically acceptable salt forms thereof, wherein M is a ring, P is an optional ring, and P4 and M4 are as defined below. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.

Facile Preparation of Monothio-orthoesters

O-Alkyl arenecarbothioates react with sodium alkoxide and alkyl halides to give monothio-orthoesters in good yield.

THIONO AND DITHIOCARBOXYLIC ESTERS WITH ADDITIONAL FUNCTIONAL GROUPS

Since powerful nucleophiles and reductants or electrophiles are required for the synthesis of thiono and dithio esters, severe difficulties arise if certain other functional groups are present in the precursor.Furthermore, strong interference may occur between a reactive substituent and the thio ester group once they are both present in a molecule. - It is, therefore, necessary - and possible - to choose thoroughly a selective method, if thiono or dithio esters with halogeno, nitro, or oxo substituents as well as bis-thiono and bis-dithio esters are to be prepared.