77573-44-5 Usage
Uses
Ingenol-3,4:5,20-diacetonide is a derivative of Ingenol (I655795), the analogue of Ingenol 3-Angelate (I655800), which has anti-tumor activity when used topically for the treatment of actinic keratosis.
Check Digit Verification of cas no
The CAS Registry Mumber 77573-44-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,7,5,7 and 3 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 77573-44:
(7*7)+(6*7)+(5*5)+(4*7)+(3*3)+(2*4)+(1*4)=165
165 % 10 = 5
So 77573-44-5 is a valid CAS Registry Number.
InChI:InChI=1/C26H36O5/c1-13-11-25-14(2)9-17-18(22(17,3)4)16(19(25)27)10-15-12-28-23(5,6)30-21(15)26(25)20(13)29-24(7,8)31-26/h10-11,14,16-18,20-21H,9,12H2,1-8H3
77573-44-5Relevant articles and documents
On the Chemistry of Ingenol, I. Ingenol and Some of its Derivatives
Opferkuch, H. J.,Adolf, W.,Sorg, B.,Kusumoto, S.,Hecker, E.
, p. 878 - 887 (2007/10/02)
The tetracyclic polyfunctional diterpene ingenol (1) is the prototype of many diterpenoid parent alcohols of the ingenane type.Esters of these parent alcohols occur-partly together with esters of polyfunctional diterpene parent alcohols of the tigliane and daphnane type - as irritant, cocarcinogenic and antineoplastic principles in spesies of the family Euphorbiaceae (Spurge).Preparation of 1 from latex of Euphorbia ingens E.May as well as of some functional derivatives of 1 are described. - Key words: Cocarcinogens, Diterpene Esters, Euphorbiaceae, Tumor Promoters