77609-11-1

Upstream product

• 959-23-9 4'-methoxychalcone 
• 109-77-3 malononitrile 
• 22966-19-4 trans-4'-methoxychalcone 

Downstream Products

• 1008787-89-0 (S)-2-[3-(4-methoxyphenyl)-3-oxo-1-phenylpropyl]malononitrile 
• 78564-28-0 2-Cyanomethylsulfanyl-6-(4-methoxy-phenyl)-4-phenyl-nicotinonitrile 
• 78564-36-0 3-Amino-6-(4-methoxy-phenyl)-4-phenyl-thieno[2,3-b]pyridine-2-carbonitrile 
• 94360-17-5 2-Bromo-2-[3-(4-methoxy-phenyl)-3-oxo-1-phenyl-propyl]-malononitrile 
• 94360-23-3 2-Chloro-2-[3-(4-methoxy-phenyl)-3-oxo-1-phenyl-propyl]-malononitrile 
• 94360-31-3 2-Bromo-6-(4-methoxy-phenyl)-4-phenyl-nicotinonitrile 
• 78564-18-8 6-(4-methoxyphenyl)-4-phenyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile 

Relevant academic research and scientific papers

Conjugate addition of malononitrile on chalcone: Biocatalytic [Formula presented] bond formation

An efficient, cost effective and environmentally friendly protocol has been developed for the Michael addition of malononitrile on 1,3-diaryl-2-propen-1-ones (Chalcones) using very cheaper, easily available natural catalyst, baker's yeast. The whole cells of yeast excellently worked in nonaqueous medium, ethanol without decrease in catalytic activity.

Cu(II)-Promoted Cascade Synthesis of Fused Imidazo-Pyridine-Carbonitriles

A Cu(II)-promoted synthesis of an aza-fused N-heterocycle having a benz-imidazopyridine scaffold is developed via an addition-cyclization reaction followed by an Ullmann-type C-N coupling between o-iodoanilines and γ-ketodinitriles. This protocol features a broad substrate scope, giving products in 32-84% yields. The compounds show excellent photoluminescence properties having two absorption maxima in the region between 270-280 and 338-350 nm and emission maxima in the range of 502-533 nm. The HOMO-LUMO energy gap of 3.49-3.57 eV was determined using Gaussian 09 at the B3LYP/6-31G (d, p) basis set level. We also demonstrated a few postsynthetic modifications.

Visible-light-accelerated pd-catalyzed cascade addition/ cyclization of arylboronic acids to γ- And β-ketodinitriles for the construction of 3-cyanopyridines and 3-cyanopyrrole analogues

The one-pot synthetic strategies for 2,4,6-triarylnicotinonitriles and 2,5-diaryl-1H-pyrrole-3-carbonitriles have been accomplished via a Pd-catalyzed coupling of arylboronic acid with 2-(3-oxo-1,3-diarylpropyl)malononitrile and 2-(2-oxo-2- arylethyl)malo

A mild and convenient one-pot synthesis of 4,6-diaryl- 3-aminoisoxazolo[3, 4-b]pyridines

We have developed a convenient method for the synthesis of a series of new 4,6-diaryl-3-aminoisoxazolo[3,4-b]pyridines through one-pot reaction starting from the easily available chalcones, malononitrile, and hydroxylamine. This class of compounds might h

An active and selective heterogeneous catalytic system for Michael addition

Potassium fluoride doped natural zeolite was found to be an efficient and selective solid base catalyst for 1,4-Michael addition. The catalyst is easily prepared and the workup procedure simplified by simple filtration. All products were obtained in high

Back to natural cinchona alkaloids: Highly enantioselective Michael addition of malononitrile to enones

An efficient and convenient highly enantioselective Michael addition of malononitrile to enones has been developed by using quinine as the organocatalyst. The adducts were isolated in excellent yield and high asymmetric induction (up to 95% ee). An easy r

Michael addition of active methylene compounds to α, β-unsaturated carbonyl compounds under the influence of molecular sieves in dimethyl sulfoxide

The Michael addition of active methylene compounds to α, β-unsaturated carbonyl compounds in the presence of MS 4A in dimethyl sulfoxide proceeds smoothly to afford the corresponding 1,4-addition products in good to high yields. Copyright

Stereoselective reductive radical cyclization of ketonitriles catalyzed by Cp2TiCl2 in the presence of chlorosilane and zinc

Reductive radical cyclization of ketonitriles was catalyzed by Cp2TiCl2 in the presence of Me3SiCl, zinc powder and imidazole, giving the 2-amino-3-cyano-2-cyclopenten-1-ols in moderate to good yields with high trans selec

SYNTHESIS AND SOME REACTIONS OF 3-CYANOPYRIDINE-2-THIONES

New method for the synthesis of 3-cyanopyridine-2-thiones by the reaction of δ-keto nitroles with sulfur and by condensation of chalcones or benzylideneacetone with cyanothioacetamide are given.The compounds obtained were used in various reactions for the preparation of alkylated products, disulfides, and condensed heterocycles, viz., thienopyridines and pyridothienopyrimidines.