77609-18-8Relevant academic research and scientific papers
A rapid one-pot synthesis of 2,4,6-triaryl-3-aroyl-4-hydroxy-1,1-cyclohexanedicarbonitriles and 2-aminoisophthalonitriles under microwave activation
Laskar, Dhrubojyoti D.,Prajapati, Dipak,Sandhu, Jagir S.
, p. 135 - 139 (2007/10/03)
Ylidenemalononitriles 1 react with a variety of 1,3-diaryl-2-propen-1-ones 2 at ambient temperature and pressure under microwave activation to yield functionalised cyclohexanedicarbonitriles 3 and 2-aminoisophthalonitriles 4 in good yields.
SYNTHESIS OF 4-AMINO-8-CYANOQUINAZOLINES FROM ENONES AND ENALS
Victory, Pedro,Borrell, Jose I.,Vidal-Ferran, Anton,Montenegro, Elvira,Jimeno, M. Luisa
, p. 2273 - 2280 (2007/10/02)
The treatment in a sodium methoxide/methanol solution of α,β-unsaturated enones or aldehydes with propanedinitrile in a 1:2 molar ratio led to 2-aminobenzene-1,3-dicarbonitriles.These compounds afforded 4-amino-8-cyanoquinazolines by reaction with formamide or guanidine.
The reaction of malononitrile with chalcone: A controversial chemical process
Victory, Pedro,Borrell, Jose I.,Vidal-Ferran, Anton,Seoane, Carlos,Soto, Jose L.
, p. 5375 - 5378 (2007/10/02)
Given the significant discrepancies in the several reported results on the reaction of chalcone (1,3-diphenyl-2-propne-1-one) (1) with malononitrile (2), a careful reinvestigation was carried out. Depending upon the reaction conditions either the open-chain Michael adduct (4), an alkoxypyridine (5), an aminoisophthalonitrile (6) or a cyclohexanol (7) is obtained. However, no 4H-pyran could be isolated from this reaction.
New aspects of Michael reaction: Reaction of 1,3-diarylpropenones with active cyano compounds
El-Sadany, S K,Sharaf, S M,Darwish, A I,Youssef, A A
, p. 567 - 573 (2007/10/02)
Ethyl 2-cyano-5-oxo-3,5-diarylpentanoates (7a-k) and 1,3,5-triaryl-2-aroyl-4-cyano-4-carboethoxycyclohexanols (6a-e,g,i,k) are obtained when the corresponding 1,3-diarylpropenones (1a-k) are reacted with ethyl cyanoacetate in the presence of different ratios of ethoxide ion.The cyclic products (6) are also obtained by treating the corresponding mono-condensation products (7) with sodium ethoxide.Furthermore, 3-aryl-4-benzoyl-2-phenylbutyronitriles (8) are obtained from the reaction of 1 with benzylcyanide in equimolar amounts in the presence of sodium ethoxide. 2-Benzoyl-4-cyano-1,3,4,5-tetraphenylcyclohexanol (9) is however, obtained when two moles of 1a are treated with one mole of benzylcyanide in the presence of ethoxide ion.The mono-condensation product 8 when treated with sodium ethoxide does not give 9.The cyclohexanol compound 11a is also obtained by the reaction of 1a with malononitrile.The structures of all the compounds have been established by elemental analysis and spectral data (IR, UV, 1H NMR and 13C NMR).
