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"3-(tetrahydro-2H-pyran-2-yloxy)-12,13-epoxytrichothec-9-ene-4,15-diyl diacetate" is a complex organic compound belonging to the family of trichothecene mycotoxins. These mycotoxins are secondary metabolites produced by certain fungi, particularly Fusarium species, and are known for their toxic effects on humans and animals. The compound is characterized by its unique molecular structure, which includes a tetrahydro-2H-pyran-2-yloxy group, an epoxy ring, and two acetate groups. This specific chemical structure contributes to its potential toxicity and biological activity. The compound's name reflects its molecular composition, with the "3-(tetrahydro-2H-pyran-2-yloxy)" indicating the presence of a tetrahydro-2H-pyran-2-yloxy group at the third carbon, the "12,13-epoxytrichothec-9-ene" part referring to the epoxy group between the 12th and 13th carbons in the trichothecene ring system, and the "4,15-diyl diacetate" denoting the presence of two acetate groups attached to the 4th and 15th carbons. 3-(tetrahydro-2H-pyran-2-yloxy)-12,13-epoxytrichothec-9-ene-4,15-diyl diacetate is of interest in the field of toxicology and may have implications for food safety and public health due to its potential presence in contaminated food products.

77620-40-7

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77620-40-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 77620-40-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,7,6,2 and 0 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 77620-40:
(7*7)+(6*7)+(5*6)+(4*2)+(3*0)+(2*4)+(1*0)=137
137 % 10 = 7
So 77620-40-7 is a valid CAS Registry Number.

77620-40-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 12,13-epoxytrichothec-9-ene-3α,4β,15-triol 4β,15-diacetate 3α-tetrahydropyranyl acetal

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:77620-40-7 SDS

77620-40-7Relevant academic research and scientific papers

Synthesis and biological activity of C-4 and C-15 Aryl azide derivatives of anguidine

Richardson, Stewart K.,Jeganathan, Alwarsamy,Mani, Rajarathnam S.,Haley, Boyd E.,Watt, David S.,Trusal, Lynn R.

, p. 2925 - 2934 (2007/10/02)

Potential trichothecene photoaffinity reagents were prepared by coupling either the C-4 or C-15 alcohols derived from anguidine with (3-azido-5-methoxyphenoxy) acetic acid, 4-(3-azido-5-methoxyphenoxy)butyric acid, or N-(3-azido-5-methoxyphenyl) N'-(carbo

Trichothecene degradation studies. 2. Synthesis of [13-14C]anguidine

Roush, William R.,Russo-Rodriguez, Sandra

, p. 598 - 603 (2007/10/02)

An efficient degradation and resynthesis of anguidine that pivots around norketone 4 is described. The sequence from anguidine to anguidine via 4 proceeds in 12 steps with an overall yield of 30%. This work has permitted for the first time the preparation of an enantiomerically pure, high specific activity 14C-labeled epoxytrichothecene mycotoxin required for biological investigations. The radiolabel was introduced by the reaction of 4 with [14C]CH2PPh3.

Trichothecene degradation studies. 3. Synthesis of 12,13-deoxy-12,13-methanoanguidine and 12-epianguidine, two optically active analogues of the epoxytrichothecene mycotoxin anguidine

Roush, William R.,Russo-Rodriguez, Sandra

, p. 603 - 606 (2007/10/02)

The title compounds were synthesized in order to further explore the apparent requirement of the trichothecene 12,13-epoxide unit for biological activity. Cyclopropane analogue 4 was prepared via a sequence involving a Simmons-Smith cyclopropanation of the anguidine degradation intermediate 6, whereas the key step in the synthesis of 12-epianguidine (5) was the dimethylsulfonium methylide mediated cyclopropanation of norketone 9. These compounds are among the first skeletally modified, semisynthetic trichothecene analogues to be prepared for biological evaluation.

CONVERSION OF ANGUIDINE INTO CALONECTRIN AND 3-DEACETYL-CALONECTRIN

Jeker, Nicolas,Mohr, Peter,Tamm, Christoph

, p. 5637 - 5640 (2007/10/02)

Anguidine (diacetoxyscirpenol, 2) was converted into calonectrin (3) in 7 steps using the Barton deoxygenation as key reaction.

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