77651-20-8

Basic information

• Product Name: methyl 3-bromo-3-phenyl-2-oxopropanoate
• Synonyms: methyl 3-bromo-3-phenyl-2-oxopropanoate
• CAS NO: 77651-20-8
• Molecular Weight: 257.084
• Mol File: 77651-20-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: methyl 3-bromo-3-phenyl-2-oxopropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-bromo-3-phenyl-2-oxopropanoate(77651-20-8)
• EPA Substance Registry System: methyl 3-bromo-3-phenyl-2-oxopropanoate(77651-20-8)

Safety Data

• Hazardous Substances Data: 77651-20-8(Hazardous Substances Data)

Upstream product

• 90179-18-3 (erythro-threo)-methyl-2-cyano-3-fluoro-2-hydroxy-3-phenylpropanoate 
• 100-52-7 benzaldehyde 
• 19190-80-8 methyl 3-Phenylglycidate 

Downstream Products

• 1373888-89-1 methyl (Z)-2-[1-(((benzyloxy)carbonyl)amino)prop-1-en-1-yl]-5-phenyloxazole-4-carboxylate 
• 62142-77-2 dimethyl 2-oxo-3,4-diphenyl-2,3-dihydrofuran-3,5-dicarboxylate 

Relevant articles and documents

Dynamic kinetic asymmetric transformations of β-halo-α-keto esters by N,N′-dioxide/Ni(II)-catalyzed carbonyl-ene reaction

Dynamic kinetic asymmetric transformations of racemic β-halo-α-keto esters through carbonyl-ene reaction were realized using a chiral N,N′-dioxide-nickel(ii) complex, giving the corresponding β-halo-α-hydroxy esters containing two vicinal chiral tri- and tetrasubstituted carbon centers in good yields and dr with excellent ee values without the use of extra bases. Meanwhile, a proposed reaction mechanism was presented according to the configuration of the product.

Regioselective ring opening of 3-aryl-2-cyano-2-(methoxycarbonyl)oxiranes with metal halides and silica-gel-supported metal halides. Synthesis of substituted but-3-en-4-olides.

Regioselective ring opening of 3-aryl-2-cyano-2-(methoxycarbonyl)oxiranes 1 with transition metal halides (copper(II) chloride, copper (II) bromide, zinc bromide, cobalt chloride and ferric chloride) and silica-gel-supported metal halides gave methyl 3-aryl-2-cyano-3-halo-2-hydroxypropanoates 5, 6 and methyl 3-aryl-3-halo-2-oxopropanoates 2, 3.The reaction of 1 in chlorobenzene under reflux with silica-gel-supported copper (II) halides gave but-3-en-4-olides 4.Key Words: methyl 3-aryl-2-cyano-3-halo-2-hydroxypropanoates; methyl 3-aryl-3-halo-2-oxopropanoates; but-3-en-4-olides.