7766-62-3Relevant academic research and scientific papers
Direct vinylation and difluorovinylation of arylboronic acids using vinyl- and 2,2-difluorovinyl tosylates via the Suzuki-Miyaura cross coupling
Gogsig, Thomas M.,Sobjerg, Lina S.,Lindhardt, Anders T.,Jensen, Kim L.,Skrydstrup, Troels
, p. 3404 - 3410 (2008/09/21)
(Chemical Equation Presented) General reaction conditions were developed for the Pd(0)-catalyzed Suzuki-Miyaura coupling reaction of aryl boronic acids with a simple electrophilic vinylation reagent, vinyl tosylate, providing access to styrene derivatives in good yields. The easily accessible vinyl tosylate represents a stable and less toxic alternative to the vinyl halides and the triflate/nonaflate derivatives. Furthermore, this methodology was expanded to provide a facile and straightforward approach for the introduction of a gem-difluorovinyl substituent onto an aromatic ring using the similar and also readily available 2,2-difluorovinyl tosylate as the electrophilic complement.
Process for the preparation of aromatic vinyl compounds
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, (2008/06/13)
A process is described for preparing aromatic vinyl compounds of general formula (I) Ar CH=CH2]nwhich is characterised in that an aromatic acetylene compound of general formula (II) Ar C≡CH]nis selectively hydrogenated at the triple bond on a noble metal catalyst. This process permits ease of access to functional aromatic vinyl compounds. It makes it possible to prepare technically pure products without expensive process measures.
