83813-73-4Relevant academic research and scientific papers
INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR KINASES
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Paragraph 001412-001414, (2021/12/28)
Provided herein are heteroaryl inhibitors of fibroblast growth factor receptor kinases, pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of diseases.
TYK2 INHIBITORS AND USES THEREOF
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Paragraph 1686-1688, (2020/05/14)
The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
Asymmetric Coupling of Carbon-Centered Radicals Adjacent to Nitrogen: Copper-Catalyzed Cyanation and Etherification of Enamides
Chen, Pinhong,Fu, Liang,Li, Yibiao,Liu, Guosheng,Zhang, Guoyu,Zhou, Song,Zou, Jianping
supporting information, p. 20439 - 20444 (2020/09/07)
The first copper-catalyzed asymmetric cyanation and etherification reactions of enamides have been established, where a carbon-centered radical adjacent to a nitrogen atom (CRAN) is enantioselectively trapped by a chiral copper(II) species. Moreover, the asymmetric cyanation of vinyl esters was disclosed as well. These reactions feature very mild reaction conditions and high functional group tolerance, and give a series of chiral α-cyano amides, α-cyano esters and α-hemiaminals in good yields with excellent enantioselectivity. The chiral α-cyano amides can be easily converted into enantioenriched 1,2-diamines and amino acids.
Direct N-gem-difluorocyclopropylation of nitro-heterocycles by utilizing gem-difluorocyclopropyl tosylate
Gu, Wei-Peng,Lin, Jin-Hong,Xiao, Ji-Chang
, p. 24 - 28 (2014/02/14)
We have developed an efficient method to achieve N-gem- difluorocyclopropylation of N-heterocycles with the use of gem- difluorocyclopropyl tosylate as a building block under mild conditions. gem-Difluorocyclopropyl tosylates could be easily prepared on a large scale and exhibit great stability.
Direct vinylation and difluorovinylation of arylboronic acids using vinyl- and 2,2-difluorovinyl tosylates via the Suzuki-Miyaura cross coupling
Gogsig, Thomas M.,Sobjerg, Lina S.,Lindhardt, Anders T.,Jensen, Kim L.,Skrydstrup, Troels
, p. 3404 - 3410 (2008/09/21)
(Chemical Equation Presented) General reaction conditions were developed for the Pd(0)-catalyzed Suzuki-Miyaura coupling reaction of aryl boronic acids with a simple electrophilic vinylation reagent, vinyl tosylate, providing access to styrene derivatives in good yields. The easily accessible vinyl tosylate represents a stable and less toxic alternative to the vinyl halides and the triflate/nonaflate derivatives. Furthermore, this methodology was expanded to provide a facile and straightforward approach for the introduction of a gem-difluorovinyl substituent onto an aromatic ring using the similar and also readily available 2,2-difluorovinyl tosylate as the electrophilic complement.
Facile C(sp2)/O2CR bond cleavage by Ru or Os
Ferrando, German,Coalter III, Joseph N.,Gerard, Helene,Huang, Dejian,Eisenstein, Odile,Caulton, Kenneth G.
, p. 1451 - 1462 (2007/10/03)
[RuHC1L2]2, L = PiPr3, reacts with H2C=CH(O2CR) (R = CH3, CF3, C6H5) during mixing at 20 °C, via two observable intermediates, to give RuCl(Osub
