70933-58-3

Usage

Uses

Used in Pharmaceutical Industry:
N-(3-Ethynylphenyl)acetamide is employed as a precursor in the synthesis of various pharmaceutical drugs and other organic compounds. Its unique structure allows for the development of new medications with potential therapeutic applications.
Used in Organic Synthesis:
As a building block in organic synthesis, N-(3-Ethynylphenyl)acetamide is used to create a range of organic compounds for different purposes, including the development of new materials and chemical intermediates.
Used in Antimicrobial Applications:
Leveraging its antimicrobial properties, N-(3-Ethynylphenyl)acetamide can be utilized in applications where the inhibition of microbial growth is required, such as in the development of antimicrobial coatings or in the formulation of cleaning products.
Used in Antifungal Applications:
Similarly, its antifungal characteristics make N-(3-Ethynylphenyl)acetamide a candidate for use in antifungal products, potentially contributing to the treatment of fungal infections or the preservation of materials susceptible to fungal decay.
Used in Neurotransmitter Research:
As a mild inhibitor of butyrylcholinesterase, N-(3-Ethynylphenyl)acetamide can be used in research related to the neurotransmitter acetylcholine, aiding in the study of neurological disorders and the development of treatments targeting the cholinergic system.

Upstream product

• 54060-30-9 3-acetylenephenylamine 
• 75-36-5 acetyl chloride 
• 75-05-8 acetonitrile 
• 60-35-5 acetamide 
• 766-81-4 3-bromophenylacetylene 
• 108-24-7 acetic anhydride 

Downstream Products

• 369363-61-1 N-(3-[1H-1,2,3-triazol-4-yl]phenyl)acetamide 
• 1025053-25-1 C₁₉H₁₄F₃N₃O 
• 1246471-71-5 C₁₆H₁₃N₃O₃ 
• 1380794-92-2 (E)-2-(3-acetamidophenyl)-5-phenyl-N-tosylpent-2-en-4-ynamide 
• 31665-68-6 N,N'-(Buta-1,3-diyne-1,4-diyl-bis(1,3-phenylene))diacetamide 
• 54060-30-9 3-acetylenephenylamine 

Relevant academic research and scientific papers

INHIBITORS OF HEPATITIS C VIRUS REPLICATION

The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

Preparation method of 3-aminophenylacetylene

The invention relates to the field of organic synthesis, in particular to a preparation method of 3-aminophenylacetylene. The preparation method of 3-aminophenylacetylene comprises the following steps: preparing a compound shown as formula III from a compound shown as formula I and a compound shown as formula II through a coupling reaction; preparing a compound shown as formula V from the compoundshown as the formula III. The preparation method of 3-aminophenylacetylene is short in synthetic route, low in energy consumption and environmentally friendly, and the target product can be obtainedparticularly from 3-bromophenylacetylene as a raw material through two steps of reactions. Besides, prepared 3-aminophenylacetylene is used as a raw material of an anticancer drug, so that generationof potential genotoxic impurities containing halogen and ethylenic linkage structures can be avoided effectively from the source.

A to aryl diazonium tetrafluoroborate salts with a nitrile preparation machine acid radical amine compounds (by machine translation)

The invention provides a high-efficiency, high-selective synthesis of different substituted functional group containing organic amide compound, it adopts the cuprous iodide as a catalyst, in order to aryl diazonium tetrafluoroborate salts compounds and organic nitrile compound as the reaction substrate, the reaction system by adding the organic solvent, water and alkali. The advantage of this method: cheap and easily obtained catalyst; the substrate has a high applicability; mild reaction conditions, safe and reliable; the resulting target product selectivity is close to 100%, yield is as high as 90% or more. The method solves the traditional synthetic organic amide compound of rigorous reaction conditions, the reaction selectivity is poor, the experimental procedure is complicated, the productivity is low and needs to be used for the environment of a harmful reagent and the like, it has good industrial application prospect. The invention also provides a corresponding different substituted functional group containing organic amide compound. (by machine translation)

Direct synthesis of N-arylamides via the coupling of aryl diazonium tetrafluoroborates and nitriles under transition-metal-free conditions

The direct synthesis of N-arylamides via the coupling of aryl diazonium tetrafluoroborates and nitriles under transition-metal-free conditions has been developed. The reported protocol is practical and represents an efficient method to produce functionalized amides in moderate to good yields.

Synthesis of N = 8 Armchair Graphene Nanoribbons from Four Distinct Polydiacetylenes

We demonstrate a highly efficient thermal conversion of four differently substituted polydiacetylenes (PDAs 1 and 2a-c) into virtually indistinguishable N = 8 armchair graphene nanoribbons ([8]AGNR). PDAs 1 and 2a-c are themselves easily access

Cu-Catalyzed Aminodifluoroalkylation of Alkynes and α-Bromodifluoroacetamides

The copper-catalyzed highly regioselective aminodifluoroalkylation of alkynes and α-bromodifluoroacetamides was realized for the first time. With this method, 3,3-difluoro-1H-pyrrol-2(3H)-ones were constructed in a single step from various alkynes and α-b

Selective N-acetylation of aromatic amines using acetonitrile as acylating agent

A method for N-acetylation of amines has been developed using acetonitrile as an acylating agent and in situ generated trimethylsilyl iodide as the catalyst under microwave heating condition. The reaction is selective toward aromatic amines while aliphatic amines remain intact. The process eliminates the requirement of toxic acylating reagents like acetic anhydride and acetyl chloride.

PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS

The present invention relates to 6-amino-7-deaza-purine derivatives which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular RET family kinases. The present

CG base pair recognition within DNA triple helices by modified N-methylpyrrolo-dC nucleosides

3-Aminophenyl-modified analogues of the bicyclic nucleoside N-methyl-3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one were synthesised and incorporated directly into triplex-forming oligonucleotides in order to utilise their extended hydrogen bonding motif for recogn

INHIBITORS OF HEPATITIS C VIRUS REPLICATION

The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.