77710-60-2

Basic information

• Product Name: 2'-DEOXYCYTIDYLYL(3'5')-THYMIDINEAMMONIU M
• Synonyms: 2'-DEOXYCYTIDYLYL(3'5')-THYMIDINEAMMONIU M;2'-deoxycytidyl(3'->5')-thymidine ammonium salt;2μ-Deoxycytidylyl(3μ-5μ)-thymidine ammonium salt
• CAS NO: 77710-60-2
• Molecular Formula: C19H26N5O11P.H3N
• Molecular Weight: 548.443
• Mol File: 77710-60-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: −20°C
• CAS DataBase Reference: 2'-DEOXYCYTIDYLYL(3'5')-THYMIDINEAMMONIU M(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-DEOXYCYTIDYLYL(3'5')-THYMIDINEAMMONIU M(77710-60-2)
• EPA Substance Registry System: 2'-DEOXYCYTIDYLYL(3'5')-THYMIDINEAMMONIU M(77710-60-2)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 77710-60-2(Hazardous Substances Data)

Upstream product

• 132164-60-4 Acetic acid 2-(1-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[(2-cyano-ethoxy)-diisopropylamino-phosphanyloxy]-tetrahydro-furan-2-yl}-2-oxo-1,2-dihydro-pyrimidin-4-ylcarbamoyl)-benzyl ester 
• 123618-92-8 C₄₆H₄₄N₅O₁₂PS 
• 76512-82-8 5'-O-(4,4'-dimethoxytrityl)deoxycytidine 
• 3992-42-5 2'-deoxycytidine monohydrochloride 
• 140613-57-6 5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine-3'-O-[(2-cyanoethyl)-N,N-diisopropylphosphoramidite] 
• 132164-61-5 C₃₇H₄₃N₆O₁₆P 

Relevant articles and documents

Solid-phase synthesis of backbone-modified DNA analogs by the boranophosphotriester method using new protecting groups for nucleobases

Backbone-modified DNA analogs were synthesized in good yields by the boranophosphotriester method on a solid support. The oligodeoxyribonucleoside boranophosphates, protected with 2-(azidomethyl)benzoyl groups for nucleobases, were converted into DNA and its backbone-modified analogs via the corresponding H-phosphonate intermediates. A new protecting group for the O6 position of 2′-deoxyguanosine, 4-azidobenzyl (ABn) group, was also developed. The ABn group can be quickly removed by treatment with MePPh2 and H2O in the presence of 2-mercaptoethanol.

The 2-(acetoxymethyl)benzoyl (AMB) group as a new base-protecting group, designed for the protection of (phosphate) modified oligonucleotides

The 2-(acetoxymethyl)benzoyl (AMB) group is a new base-protecting group that facilitates the synthesis of labile, modified nucleotides, since it can be rapidly cleaved under mild basic conditions.