77726-10-4Relevant academic research and scientific papers
Aromatic amino analogues of artemisinin: Synthesis and in vivo antimalarial activity
Sriram, Dharmarajan,Devakaram, Ruth Vandana,Dinakaran, Murugesan,Yogeeswari, Perumal
supporting information; experimental part, p. 524 - 532 (2011/10/31)
Nine orally active novel artemisinin derivatives were prepared from artemisinin by four-step synthesis, and the compounds were evaluated in the rodent model using multidrug resistant Plasmodium yoelii nigeriensis. All of the compounds exhibited antimalarial activities with the ED50 ranging from 5.41 mg/kg-12.4 mg/kg. Among them, artemisinin derivative bearing N-(4-hydroxy-3- ((4-phenylpiperazin-1-yl)methyl)phenyl) moiety (5f) was found to be the most active compound and was found to be three times more potent than artemisinin (ED50 16.4 mg/kg). Birkhaeuser Boston 2009.
Studies in Potential Filaricides: Part XI - Synthesis of 2-Dialkylaminomethyl-4-substitutedamino-phenols as Amodiaquine Analogs
Agrawal, V. K.,Sharma, Satyavan,Iyer, R. N.,Chatterjee, R. K.,Sen, A. B.
, p. 1084 - 1087 (2007/10/02)
A number of 4,7-disubstituted quinazolines (11-17) and 2-dialkylaminomethyl-4-acetylaminophenols (19-30) have been synthesized and tested for their antifilarial activity against Litosomoides carinii in cotton rat (Sigmodon hispidus).Of the compounds tested 19-21 and 26 cause 60percent fall in microfilarial count at a dose of 30 mg/kg given intraperitoneally daily for 6 days.None of the compounds possesses any macrofilaricidal activity.
