77736-57-3

Usage

Chemical Structure

Benzene ring attached to an amino group (-NH2) and a phenoxy group (-C6H5O)

Functional Groups

Amino group (-NH2), thiol group (-SH), phenoxy group (-C6H5O)

Applications

Pharmaceutical industry: Used as a building block in the synthesis of various pharmaceuticals.
Material science: Potential applications in the development of materials.
Organic chemistry research: Used as a reagent in organic chemistry research.

Properties

Aromatic: Contains a benzene ring, giving it aromatic properties.
Thiol derivative: Contains a thiol group (-SH), which imparts characteristic properties.
Versatile: Can participate in various chemical reactions due to the presence of multiple functional groups.

Research Interest

Unique chemical structure: Researchers are interested in its distinct chemical arrangement.
Synthetic applications: Potential for diverse synthetic and industrial applications.

Synthesis

Not provided, but likely synthesized through organic chemistry methods involving aromatic compounds and amino group functionalization.

Upstream product

• 65948-19-8 2-Amino-6-phenoxybenzothiazole 
• 1310-58-3 potassium hydroxide 
• 129121-42-2 2-amino-6-(3-methylphenoxy)benzothiazole 
• 76839-21-9 1-(4-phenoxyphenyl)-2-thiourea 
• 139-59-3 4-phenoxyanilin 

Downstream Products

• 129120-87-2 Ethyl 3-(2-amino-5-phenoxyphenyl)thio-2-hydroxy-3-(3,4-methylenedioxyphenyl)propionate 
• 1341218-16-3 ethyl 3-isopropyl-7-phenoxy-4H-1,4-benzothiazine-2-carboxylate 
• 129120-52-1 (2S,3S)-5-(2-dimethylaminoethyl)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-8-phenoxy-1,5-benzothiazepin-4(5H)-one 

Relevant academic research and scientific papers

A Novel Difluoroacetic Acid Derivatives Compound, and Composition Comprising the Same

The present invention relates to a novel difluoroacetic acid derivative compound and a composition for various uses containing the same, wherein the difluoroacetic acid derivative compound can not only act as an agonist activating one among PPARandalpha;, andbeta; or andgamma;, but also can exhibit double efficacy or triple efficacy. Therefore, the difluoroacetic acid derivative compound can more effectively prevent, alleviate or treat metabolic diseases in which PPARs involves, and further exhibits whitening and wrinkle alleviation activity, and anti-inflammatory and antioxidant effects, thereby being able to be usefully utilized as various compositions.COPYRIGHT KIPO 2020

Synthesis and antimicrobial activity of structurally flexible heterocycles with the 1,4-thiazine heterosystem

In this work, 4H-1,4-benzothiazines were synthesized by an efficient synthetic method in a single step involving heterocyclization of substituted 2-aminobenzenethiols with β-ketoester. The structures of the synthesized compounds were confirmed by their analytical and spectral data. The synthesized compounds were evaluated for their antimicrobial activity against bacterial species; E. coli and Bacillus cereus. The synthesized compounds showed significant activity against microorganisms, which can be correlated with the privileged heterocyclic structural scaffolds.

Synthesis and antihypertensive activity of 3-acetoxy-2,3-dihydro-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-1 ,5-benzothiazepin-4(5H)-one (diltiazem) derivatives having substituents at the 8 position

In order to improve the potency and duration of biological actions of diltiazem, a number of 1,5-benzothiazepine derivatives having the substituents at the 8 position were prepared and evaluated for their antihypertensive activity in spontaneously hyperte

1,5-benzothiazepine derivatives, their preparation and their use in the treatment of cardiovascular disorders

Compounds of formula (I): STR1 in which: R 1 is aryl or aromatic heterocyclic; R 2 and R 3 are hydrogen, alkyl, alkoxy, halogen, phenyl, phenoxy, C 1 -C 6 alkylthio, phenylthio, C 1 -C 6 haloalkyl, cyano or nitro, or together are alkylene optionally containing oxygen; R 4 is hydrogen, aliphatic acyl, cycloalkylcarbonyl, cycloalkoxycarbonyl, aromatic acyl, alkoxycarbonyl or benzyloxycarbonyl; R 5 and R 6 are alkyl; and X is oxygen, sulfur or methylene, have calcium channel blocking activity and can serve for the treatment or prophylaxis of cardiovascular diseases and disorders. They may be prepared by reacting a corresponding compound where R 4 is hydrogen and the aminoethyl group is replaced by hydrogen with a compound providing the aminoethyl group and the, if required, acylating the product.