65948-19-8

Usage

Uses

Used in Pharmaceutical Industry:
6-phenoxybenzo[d]thiazol-2-amine is used as a building block in the synthesis of various bioactive molecules for [application reason]. Its unique structure and properties make it a valuable component in the creation of new pharmaceutical compounds with potential therapeutic effects.
Used in Materials Science:
In the field of materials science, 6-phenoxybenzo[d]thiazol-2-amine is used in the development of new organic materials with specific properties for [application reason]. Its incorporation into these materials can lead to the creation of innovative products with tailored characteristics, such as improved stability, reactivity, or other desirable traits.
Further research and experimentation are necessary to fully explore the potential uses and properties of 6-phenoxybenzo[d]thiazol-2-amine, ensuring that its applications are maximized and its benefits are realized across different industries.

Upstream product

• 139-59-3 4-phenoxyanilin 
• 1135-14-4 4-aminophenyl phenyl sulfide 
• 101-79-1 4-amino-4'-chlorodiphenyl ether 
• 56705-84-1 4-(m-tolyloxy)aniline 
• 31465-36-8 4-(4'-methoxyphenoxy)aniline 
• 333-20-0 potassium thioacyanate 
• 1147550-11-5 ammonium thiocyanate 
• 1747-60-0 6-methoxybenzothiazol-2-ylamine 
• 26278-79-5 2-amino-6-hydroxybenzothiazole 
• 108-90-7 chlorobenzene 

Downstream Products

• 77736-57-3 2-amino-5-phenoxybenzenethiol 
• 1163713-38-9 2-[3-(1,3-dioxo-1,3-dihydroisoindol-2-yl)propoxy]-N-(6-phenoxybenzothiazol-2-yl)benzamide 
• 1188043-84-6 C₁₃H₁₁N₃OS 
• 1353280-30-4 N-butyl-6-phenoxybenzo[d]thiazol-2-amine 
• 129120-52-1 (2S,3S)-5-(2-dimethylaminoethyl)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-8-phenoxy-1,5-benzothiazepin-4(5H)-one 
• 129120-96-3 (2S,3S)-3-(2-amino-5-phenoxyphenyl)thio-2-hydroxy-3-(4-methoxyphenyl)propionic acid 

Relevant academic research and scientific papers

A Novel Difluoroacetic Acid Derivatives Compound, and Composition Comprising the Same

The present invention relates to a novel difluoroacetic acid derivative compound and a composition for various uses containing the same, wherein the difluoroacetic acid derivative compound can not only act as an agonist activating one among PPARandalpha;, andbeta; or andgamma;, but also can exhibit double efficacy or triple efficacy. Therefore, the difluoroacetic acid derivative compound can more effectively prevent, alleviate or treat metabolic diseases in which PPARs involves, and further exhibits whitening and wrinkle alleviation activity, and anti-inflammatory and antioxidant effects, thereby being able to be usefully utilized as various compositions.COPYRIGHT KIPO 2020

Visible-light photoredox catalytic approach for the direct synthesis of 2-aminobenzothiazoles from anilines

A novel, highly efficient and convenient approach for the visible-light-promoted direct synthesis of 2-aminobenzothiazoles from anilines and ammonium thiocyanate is presented. The reaction involves addition/cyclization cascade of SCN radical and anilines under photoredox catalysis with Ru(bpy)3Cl2. The salient features of the protocol include the utilization of atmospheric oxygen and visible light as clean, inexpensive and sustainable resources at room temperature.

Copper-Catalyzed Aerobic Oxidative Regioselective Thiocyanation of Aromatics and Heteroaromatics

A copper-catalyzed aerobic oxidative reaction between aromatics or heteroaromatics with KSCN is developed by using O2 as the oxidant. The combination of Cu(OTf)2, N,N,N′,N′-tetramethylethylenediamine (TMEDA) and BF3·Et2O provides an efficient catalytic system, affording substituted thiocyanation products and 2-aminobenzothiazoles in excellent yields. The reaction also possesses a good functional group tolerance for both strong electron-withdrawing and electron-donating groups.

PHENYLIMIDE-CONTAINING BENZOTHIAZOLE DERIVATIVE OF ITS SALT AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

Provided is a phenylimide-containing benzothiazole derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, and a pharmaceutical composition comprising the same. The phenylimide-containing benzothiazole derivative or its pharmaceutically acceptable salt can selectively inhibit the protein-protein interaction between KRS and a laminin receptor (LR), thereby inhibiting migration of cancer cells. Therefore, the phenylimide-containing benzothiazole derivative or its pharmaceutically acceptable salt may be usefully applied for preventing or treating the diseases associated with cancer cell metastasis.

Synthesis and anticonvulsant activity evaluation of 7-alkoxy[1,2,4] triazolo[3,4-b]benzothiazol-3(2H)-ones

A new series of 7-alkoxy[1,2,4]triazolo[3,4-b]benzothiazol-3(2H)-ones were synthesized and evaluated for their anticonvulsant activities. Among these compounds, 7-propoxy[1,2,4]triazolo[3,4-b]benzothiazol-3(2H)-one (4c) and 7-butoxy[1,2,4]triazolo[3,4-b]benzothiazol-3(2H)-one (4d) showed the highest activity against maximal electroshock (MES)-induced tonic extension [effective dose (ED)50: 11.4 and 13.6 mg/kg, respectively]. It is worth mentioning that compound 4d showed especially low neurotoxicity, which led to a high protective index (PI >51). The orally anticonvulsant activity data of compound 4d further confirmed its efficacy, in an MES test, and its high safety with a PI value of 50.2. In addition, the potency of compound 4h against seizures induced by pentylenetetrazole, 3-mercaptopropionic acid, and bicuculline in the chemical-induced seizure tests suggested that compound 4d may exert its anticonvulsant activity through affecting the GABAergic system.

2-Aminobenzothiazole derivatives: Search for new antifungal agents

A new series of 6-substituted 2-aminobenzothiazole derivatives were synthesized and screened in vitro as potential antimicrobials. Almost all the compounds showed antifungal activity. In particular, compounds 1n,o, designed on the basis of molecular modeling studies, were the best of the series, showing MIC values of 4-8 μg/mL against Candida albicans, Candida parapsilosis and Candida tropicalis. None of the two compounds did show any cytotoxicity effect on human THP-1 cells.

PHENYLIMIDE-CONTAINING BENZOTHIAZOLE DERIVATIVE OR ITS SALT AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention provides a phenylimide-containing benzothiazole derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, and a pharmaceutical composition comprising the same. The phenylimide-containing benzothiazole derivative or its pharmaceutically acceptable salt can selectively inhibit the protein-protein interaction between KRS and a laminin receptor (LR), thereby inhibiting migration of cancer cells. Therefore, the phenylimide-containing benzothiazole derivative or its pharmaceutically acceptable salt may be usefully applied for preventing or treating the diseases associated with cancer cell metastasis.

1,5-benzothiazepine derivatives, their preparation and their use in the treatment of cardiovascular disorders

Compounds of formula (I): STR1 in which: R 1 is aryl or aromatic heterocyclic; R 2 and R 3 are hydrogen, alkyl, alkoxy, halogen, phenyl, phenoxy, C 1 -C 6 alkylthio, phenylthio, C 1 -C 6 haloalkyl, cyano or nitro, or together are alkylene optionally containing oxygen; R 4 is hydrogen, aliphatic acyl, cycloalkylcarbonyl, cycloalkoxycarbonyl, aromatic acyl, alkoxycarbonyl or benzyloxycarbonyl; R 5 and R 6 are alkyl; and X is oxygen, sulfur or methylene, have calcium channel blocking activity and can serve for the treatment or prophylaxis of cardiovascular diseases and disorders. They may be prepared by reacting a corresponding compound where R 4 is hydrogen and the aminoethyl group is replaced by hydrogen with a compound providing the aminoethyl group and the, if required, acylating the product.

Benzothiazol-2-one-3-alkanoic acids and esters and aldose reductase inhibiting compositions thereof

A pharmaceutical composition comprising certain benzothiazoline alkanoic acid derivatives for the prevention and treatment of various diabetic complications, said derivatives being inhibitors of aldose reductase.