77744-16-2Relevant academic research and scientific papers
Synthesis of 3-Aryl-3-pyridylallylamines Related to Zimelidine via Palladium-Catalyzed Amination
Baeckvall, Jan-E.,Nordberg, Ruth E.,Nystroem, Jan-E.,Hoegberg, Thomas,Ulff, Bengt
, p. 3479 - 3483 (2007/10/02)
Reaction of aryl pyridyl ketones 1 with vinylmagnesium bromide followed by acetylation of the products 2 with acetic anhydride/Et3N and with 4-(dimethylamino)pyridine (DMAP) as a catalyst gave acetates 3 in high yields.Treatment of acetates 3 with dimethylamine in the presence of a palladium catalyst produced a mixture of E and Z isomers of 3-aryl-3-pyridylallylamines 4.
