77747-69-4

Basic information

• Product Name: 5-Nitroisocoumarin
• Synonyms: 5-Nitroisochromen-1-one;5-Nitroisocoumarin;5-Nitro-1H-isochroMen-1-one;1H-2-Benzopyran-1-one, 5-nitro-;5-nitro-1H-2-Benzopyran-1-one
• CAS NO: 77747-69-4
• Molecular Formula: C₉H₅NO₄
• Molecular Weight: 191.1403
• Mol File: 77747-69-4.mol
• Article Data: 11

Chemical Properties

• Melting Point: 173-174℃
• Boiling Point: 363.4±42.0 °C(Predicted)
• Appearance: /
• Density: 1.482
• CAS DataBase Reference: 5-Nitroisocoumarin(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Nitroisocoumarin(77747-69-4)
• EPA Substance Registry System: 5-Nitroisocoumarin(77747-69-4)

Safety Data

• Hazardous Substances Data: 77747-69-4(Hazardous Substances Data)

Upstream product

• 59382-59-1 2-methyl-3-nitro-benzoic acid methyl ester 
• 1975-50-4 2-methyl-3-nitrobenzic acid 
• 64-17-5 ethanol 
• 73816-11-2 Methyl trans-2-<β-(dimethylamino)vinyl>-3-nitrobenzoate 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 98475-07-1 2-bromomethyl-3-nitro-benzoic acid methyl ester 
• 59382-61-5 isopropyl 2-methyl-3-nitrobenzoate 
• 77747-70-7 3,4-dihydro-3-methoxy-5-nitroisocoumarin 

Downstream Products

• 951016-00-5 methyl 2-(4-chlorophenyl)-2-(5-nitro-1-oxoisoquinolin-2(1H)-yl)acetate 
• 64840-53-5 2-benzyl-5-nitro-1(2H)-isoquinolinone 
• 143075-63-2 2-(5-Methyl-1-trityl-1H-imidazol-4-ylmethyl)-5-nitro-2H-isoquinolin-1-one 
• 143075-64-3 5-Amino-2-(5-methyl-1-trityl-1H-imidazol-4-ylmethyl)-2H-isoquinolin-1-one 
• 1074-85-7 (1H-indol-4-yl)methanol 
• 245677-36-5 5-bromoisocoumarin 
• 190777-77-6 5-bromo-1,2-dihydroisoquinolin-1-one 
• 81251-06-1 2-(2-hydroxyethyl)-3-hydroxymethylnitrobenzene 
• 81251-05-0 3-hydroxy-5-nitroisochroman 
• 70758-25-7 5-aminoisocoumarin 
• 82827-08-5 5-nitroisoquinoline-1(2H)-one 

Relevant articles and documents

The role of polycyclic frameworks in modulating P2X7 receptor function

Herein we describe our recent attempts to target the P2X7 receptor for potential treatment of neurological disorders. This work focusses on different polycycles including carborane, adamantane or cubane, joined by either a cyanoguanidine or an amide linker to phenyl or isoquinoline moieties. We have demonstrated the superiority of the adamantyl moiety over other polycycles in terms of synthetic accessibility and biological (cellular) activity. We have also shown that an amide or cyanoguanidine linker can greatly alter the biological activity of compounds. This SAR study provides important insights into the types of functionality required to target the P2X7 receptor.

Multiply-substituted tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents

The invention relates to multiply-substituted tetrahydronaphthalene derivatives of formula (I) process for their production and their use as anti-inflammatory agents.

1-AMINO-2-OXY-SUBSTITUTED TETRAHYDRONAPHTALENE DERIVATIVES, METHODS FOR THE PRODUCTION THEREOF, AND THEIR USE AS ANTIPHLOGISTICS

The invention relates to polysubstituted tetrahydronaphtalene derivatives of formula (I), to methods for the production thereof, and to their use as antiphlogistics. The substituents are defined in Claim 1.