77761-39-8

Upstream product

• 708-06-5 2-hydroxynaphthalene-1-carbaldehyde 
• 1885-29-6 anthranilic acid nitrile 

Relevant academic research and scientific papers

Solvent-free polymorphism control in a covalent mechanochemical reaction

Four crystal modifications of a Schiff base derived from 2-hydroxy-1-naphthaldehyde and 2-aminobenzonitrile have been obtained by conventional solution-based methods. Three polymorphs out of four can be synthesized under solvent-free conditions. Herein we

Effect of atmosphere on solid-state amine-aldehyde condensations: Gas-phase catalysts for solid-state transformations

The presence of water or organic solvent vapour accelerates the solid-state condensation of solid aromatic amines and aromatic aldehydes into Schiff bases; we show the important role of catalytic triethylamine in the vapour phase in such vapour digestion

Effect of atmosphere on solid-state amine-aldehyde condensations: Gas-phase catalysts for solid-state transformations

The presence of water or organic solvent vapour accelerates the solid-state condensation of solid aromatic amines and aromatic aldehydes into Schiff bases; we show the important role of catalytic triethylamine in the vapour phase in such vapour digestion

Sirtuin Inhibiting Compounds

Provided herein are compositions and methods for treating or preventing cancer and autoimmune diseases. Compositions comprise a sirtuin inhibitory compound that decreases the activity of a sirtuin, such as SIRT1 or Sir2. Exemplary methods comprise contact

Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (sirtuin) inhibitors

In a search for potent inhibitors of class III histone/protein deacetylases (sirtuins), a series of sirtinol analogues have been synthesized and the degree of inhibition was assessed in vitro using recombinant yeast Sir2, human SIRT1, and human SIRT2 and in vivo with a yeast phenotypic assay. Two analogues, namely, 3- and 4-[(2-hydroxy-1-naphthalenylmethylene)-amino]-N-(1-phenylethyl) benzamide (i.e., m- and p-sirtinol), were 2- to 10-fold more potent than sirtinol against human SIRT1 and SIRT2 enzymes. In yeast in vivo assay, these two small molecules were as potent as sirtinol. Compounds lacking the 2-hydroxy group at the naphthalene moiety or bearing several modifications at the benzene 2′-position of the aniline portion (carbethoxy, carboxy, and cyano) were 1.3-13 times less potent than sirtinol, whereas the 2′-carboxamido analogue was totally inactive. Both (R)- and (S)-sirtinol had similar inhibitory effects on the yeast and human enzymes, demonstrating no enantioselective inhibitory effect.

Studies of Chelation. Part 9. Cobalt Complexes of 1--2-naphthol and 1--2-naphthol Ligands. Tautomerism and Reactivity

Spectroscopic characterisation (1H and 13C n.m.r., i.r., Raman, and u.v.-visible) of various 1--2-naphthols, R-Haz (R = 4'-Me, 4'-OMe, 4'-Cl, H, 2'-OMe, 2'-Me, 2'-Cl, and 2'-Br), and 1--2-naphthols, R-Hsb (R = 4'-OMe, 4'-Me, 4'-Cl, H, 4'-Br, 4'-CF3, 4'-CN, 4'-NO2, 2'-OMe, 2'-Me, 2'-CHMe2, 2'-Cl, 2'-CN, and 2'-NO2), in the solid state and in solution in both polar and non-polar solvents has shown that the hydrogen-bonded keto-tautomer is dominant in polar solvents.Reaction of cobalt(II) salts with R-Haz and with R-Hsb in ethanol produces , cis-, and fac- (L=R-az or R-sb).The tautomeric form of the ligand in these complexes is established by vibrational spetroscopy and shown to be predominantly keto (hydrazone, ketoenamine) in , in , and (X = Cl or Br) but predominantly enolimine in .The interconversion of and is established generally: the intermediate, five-co-ordinate is identified in certain cases (R = 4-OMe, 4'-Me, or H).In the chelation process, proton loss follows ring closure and is succeeded by tautomerisation where this occurs.The facility with which the chelating ligand deviates from coplanarity of the benzene and naphthalene rings is a critical feature of the chelation process.The formation of from and from in the presence of air occurs easily and is acid catalysed. is formed only under vigorously oxidising conditions.The isoelectronic ligands R-Haz and R-Hsb should not be regarded as identical in their reactivity towards cobalt(II).