777899-57-7

Usage

Uses

Used in Pharmaceutical Industry:
2-chloro-5-nitro-isonicotinic acid methyl ester is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique chemical structure allows for the development of new drugs with potential therapeutic applications. 2-chloro-5-nitro-isonicotinic acid methyl ester's reactivity and functional groups make it a versatile building block in medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 2-chloro-5-nitro-isonicotinic acid methyl ester serves as an essential intermediate for the production of various agrochemicals. Its incorporation into the synthesis process contributes to the development of effective pesticides, herbicides, and other agricultural chemicals that enhance crop protection and yield.
Used in Organic Synthesis:
2-chloro-5-nitro-isonicotinic acid methyl ester is used as a valuable building block in the synthesis of diverse heterocyclic compounds. Its presence in the molecular structure allows for the formation of complex organic compounds with potential applications in various industries, including pharmaceuticals, materials science, and specialty chemicals.
Used in Research and Development:
2-chloro-5-nitro-isonicotinic acid methyl ester's unique properties and reactivity make it an attractive candidate for research and development in the field of organic chemistry. Scientists and researchers utilize 2-chloro-5-nitro-isonicotinic acid methyl ester to explore new synthetic pathways, develop novel compounds, and investigate its potential applications in various chemical processes.

Upstream product

• 23056-33-9 2-chloro-4-methyl-5-nitro-pyridine 
• 75-09-2 dichloromethane 
• 18107-18-1 diazomethyl-trimethyl-silane 

Downstream Products

• 777899-58-8 2-(2,4-Difluoro-phenoxy)-5-nitro-isonicotinic acid methyl ester 
• 1198165-14-8 methyl 2-(4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-2-propylphenoxy)-5-nitroisonicotinate 
• 1073182-59-8 methyl 5-amino-2-chloroisonicotinate 
• 139004-86-7 methyl 6-methyl-3-nitro-4-pyridinecarboxylate 
• 860369-48-8 methyl 5-amino-2-methylisonicotinate 

Relevant academic research and scientific papers

FGFR4 inhibitor and preparation method and application thereof

The invention relates to an FGFR4 inhibitor and a preparation method and application thereof, in particular to a medicine composition of the FGFR4 inhibitor with a structure shown in the formula (I).The medicine composition has a high inhibiting effect on FGFR4 kinase activity, and can be widely applied to preparation of medicine for treating cancers including the liver cancer, the stomach cancer, the prostatic cancer, the skin cancer, the ovarian cancer, the lung cancer, the breast cancer and the colon cancer.

FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF

Provided are an FGFR4 inhibitor having the structure of formula (I), and a preparation method therefor and the use thereof. The compound has a very strong inhibitory effect on FGFR4 kinase activity and has a very high selectivity, and can be widely used in the preparation of a drug for treating cancers, especially prostate cancer, liver cancer, pancreatic cancer, esophageal carcinomas, gastric cancer, lung cancer, breast cancer, ovarian carcinomas, colon cancer, skin cancer, glioblastomas or rhabdomyosarcomas, and is expected to be developed into a new generation of FGFR4 inhibitor drugs.

TETRAHYDRONAPHTHYRIDINE DERIVATIVES AS mGluR2-NEGATIVE ALLOSTERIC MODULATORS, COMPOSITIONS, AND THEIR USE

Provided are quinoline carboxamide and quinoline carbonitrile compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein R 1, R 2, L, X 1, X 2, and X 3, are as defined herein. The compounds of the invention, and pharmaceutically acceptable salts thereof, and pharmaceutical compositions comprising them, are useful as non-competitive mGluR2 antagonists, or mGluR2 negative allosteric modulators (NAMs), and may be useful in methods of treating a person in need thereof for diseases or disorders in which the mGluR2-NAM receptor plays a causative role, such as Alzheimer's disease, cognitive impairment, schizophrenia and other mood disorders, pain disorders and sleep disorders.

SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL USE THEREOF

Provided is a sulfonamide derivative represented by the following general formula (1) and having an α4 integrin inhibitory effect with high selectivity with a low effect on α4β1 and a high effect on α4β7, or a pharmaceutically acceptable salt thereof (in the general formula (1), A, B, D, E, R41, and a to h are as described in the description).

SULFONAMIDE DERIVATIVE AND MEDICINAL USE THEREOF

Provided are sulfonamide derivatives of a specific chemical structure in which a sulfonamide group having, as a substituent, a phenyl group or a heterocyclic group having a hetero atom(s) as a constituent element(s) is present at its terminal, and pharmaceutically acceptable salts thereof. These compounds are novel compounds having excellent α4 integrin-inhibitory action.

CONDENSED AZINE - DERIVATIVES FOR THE TREATMENT OF DISEASES RELATED TO THE ACETYLCHOLINE RECEPTOR

The present invention relates to a heterocyclic derivative of formula (I) wherein the variables are as defined in the specification or to a pharmaceutically acceptable salt or solvate thereof. The present invention further relates to pharmaceutical compositions comprising said heterocyclic derivatives and to their use in therapy, for instance in the treatment or prevention of disorders mediated by nicotinic acetylcholine receptors, such as schizophrenia and Alzheimer's disease.

CARBINOL DERIVATIVES HAVING CYCLIC LINKER

[Object] To provide a novel LXRβ agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease. [Solving Means] A carbinol compound represented by the following general formula (I) or salt thereof, or their solvate.

Substituted 7-azaquinazoline compounds useful as p38 kinase inhibitors

Compounds having the formula (I) or (II), are useful as p38 kinase inhibitors, wherein R is an optionally substituted alkyl, cycloalkyl, or aryl; R6 is hydrogen or lower alkyl; R7 is hydrogen or a non-interfering substituent, and Q is a non-aromatic moiety as defined in the specification.