139004-86-7

Basic information

• Product Name: 4-Pyridinecarboxylicacid,2-methyl-5-nitro-,methylester(9CI)
• Synonyms: 4-Pyridinecarboxylicacid,2-methyl-5-nitro-,methylester(9CI);Methyl 2-methyl-5-nitroisonicotinate
• CAS NO: 139004-86-7
• Molecular Formula: C₈H₈N₂O₄
• Molecular Weight: 196.16
• Product Categories: AMINOACID
• Mol File: 139004-86-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Pyridinecarboxylicacid,2-methyl-5-nitro-,methylester(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Pyridinecarboxylicacid,2-methyl-5-nitro-,methylester(9CI)(139004-86-7)
• EPA Substance Registry System: 4-Pyridinecarboxylicacid,2-methyl-5-nitro-,methylester(9CI)(139004-86-7)

Safety Data

• Hazardous Substances Data: 139004-86-7(Hazardous Substances Data)

Upstream product

• 777899-57-7 2-chloro-5-nitro-isonicotinic acid methyl ester 
• 823-96-1 Trimethylboroxine 
• 907545-47-5 2-chloro-5-nitro-pyridine-4-carboxylic acid 
• 23056-33-9 2-chloro-4-methyl-5-nitro-pyridine 
• 20845-23-2 methyl 1-methyl-2-oxo-1,2-dihydropyridine-4-carboxylate 
• 139004-71-0 methyl 1 methyl-3,5-dinitro-6-oxo-1,6-dihydro-2-pyridinecarboxylate 
• 67-64-1 acetone 
• 139004-72-1 methyl 1-methyl-3,5-dinitro-2-oxo-1,2-dihydro-4-pyridinecarboxylate 

Downstream Products

• 860369-48-8 methyl 5-amino-2-methylisonicotinate 

Relevant articles and documents

TETRAHYDRONAPHTHYRIDINE DERIVATIVES AS mGluR2-NEGATIVE ALLOSTERIC MODULATORS, COMPOSITIONS, AND THEIR USE

Provided are quinoline carboxamide and quinoline carbonitrile compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein R 1, R 2, L, X 1, X 2, and X 3, are as defined herein. The compounds of the invention, and pharmaceutically acceptable salts thereof, and pharmaceutical compositions comprising them, are useful as non-competitive mGluR2 antagonists, or mGluR2 negative allosteric modulators (NAMs), and may be useful in methods of treating a person in need thereof for diseases or disorders in which the mGluR2-NAM receptor plays a causative role, such as Alzheimer's disease, cognitive impairment, schizophrenia and other mood disorders, pain disorders and sleep disorders.

REGIOSELECTIVE SYNTHESIS OF 2-SUBSTITUTED 3-NITROPYRIDINES BY ONE-POT REACTION OF EITHER 4- OR 6-SUBSTITUTED 1-METHYL-3,5-DINITRO-2-PYRIDONES WITH KETONES AND AMMONIA

Regioselective synthesis of 2-substituted 3-nitropyridines was achieved by one-pot reaction of either 4- or 6-substituted 1-methyl-3,5-dinitro-2-pyridones with ketones in the presence of ammonia.The selectivity is interpreted in terms of steric factor of substituent on the pyridone.