77819-95-5Relevant academic research and scientific papers
Investigation of 8-methoxy-3-(4-nitrobenzoyl)-6-propyl-2H-chromen-2-one as a promising coumarin compound for the development of a new and orally effective antileishmanial agent
de Figueiredo Peloso, Eduardo,Merli, Rafaella Junqueira,Espuri, Patrícia Ferreira,Nunes, Juliana Barbosa,Colombo, Fábio Ant?nio,Sierra, Elkin José Torres,de Paulo, Daniela Carvalho,dos Santos, Marcelo Henrique,Carvalho, Diogo Teixeira,Marques, Marcos José
, p. 8465 - 8474 (2020)
Changes in host immunity and parasite resistance to drugs are among the factors that contribute to decreased efficacy of antiparasitic drugs such as the antimonial compounds pentamidine, amphotericin (AMP B) and miltefosine. Bioactive natural products cou
Synthesis of 3-Substituted coumarins: An efficient green approach using l-Proline as catalyst in triethanolamine medium
Srikrishna, Devulapally,Tasqeeruddin, .Syed,Dubey, Pramod Kumar
, p. 556 - 563 (2014/07/21)
3-Substituted coumarins were synthesized very efficiently, using Knoevenagel method from salicylaldehydes 1 and active methylene compounds 2 under green conditions. The effect of catalyst and solvent on this condensation was studied. L-Proline was found t
Asymmetric conjugate additions to 1,1′-diactivated cyclic enones-a comparative study
Tang, Xiaoping,Blake, Alexander J.,Lewis, William,Woodward, Simon
experimental part, p. 1881 - 1891 (2010/02/27)
A study of copper-phosphoramidite-catalysed ZnR2 and AlR3 additions to 1,1′-dicarbonyl-activated cyclic Michael acceptors has revealed high enantioselectivities for AlR3 (R = Me, Et) 1,4-addition to a range of 3-acylcoumarins (85-98% ee, trans:cis ～90:10) using commercial or readily available ligands. Large substituents at the 6-position, and to some extent at the 5-position, of the coumarin are less well tolerated, nor is truncation of the coumarin motif to a comparable 2-acylcyclohexenone (ee values up to 78%).
Solvent-free coumarin synthesis
Sugino, Teizo,Tanaka, Koichi
, p. 110 - 111 (2007/10/03)
The synthesis of coumarins via Pechmann and Knoevenagel condensation reactions under solvent-free conditions is reported, in which waste minimization, simple operation and easier product work-up can be achieved.
