77819-97-7Relevant articles and documents
Metal-Free, Regioselective, Dehydrogenative Cross-Coupling between Formamides/Aldehydes and Coumarins by C–H Functionalization
Gupta, Mohit,Kumar, Prashant,Bahadur, Vijay,Kumar, Krishan,Parmar, Virinder S.,Singh, Brajendra K.
, p. 896 - 900 (2018)
A highly efficient, single-step, metal-free synthetic approach to the synthesis of coumarin-3-carboxamides has been developed. The protocol employs tert-butyl peroxybenzoate as a radical initiator to achieve the regioselective carboxamidation of coumarins at C-3 in good-to-moderate yields. The established reaction protocol offers a wide substrate scope as it allows the use of both formamides as well as aldehydes as coupling partners with excellent regioselectivity. Furthermore, mechanistic investigations illustrate that the reaction proceeds by a free-radical pathway.
