77828-28-5

Upstream product

• 20281-69-0 5α-cholest-2-en-6-one 
• 17887-53-5 1-trimethylsilanyl-1H-indazole 
• 26654-81-9 (5R,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-Dimethyl-hexyl)-10,13-dimethyl-1,4,5,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-6-one 
• 75-77-4 chloro-trimethyl-silane 
• 10416-59-8 N,O-Bis(trimethylsilyl)acetamide 
• 27948-74-9 6β-hydroxy-5α-cholest-2-ene 

Relevant academic research and scientific papers

Potassium Borohydride Reductions of Ketones absorbed into Polymer Supports: Stereochemical Effects

The proportions of 6α-alcohol obtained from aqueous potassium borohydride reductions of 3β-cholestan-6-one (1) absorbed into various polymers varied from 0 to 90percent depending on the polymer used and whether or not a phase transfer catalyst was added; some other ketones show similar streochemical effects, the greatest effects probably arising when the substrates are adsorbed to the inner surfaces of appropriate polymers.

Influence of the 6-trimethylsilyl group on the fragmentation of the trimethylsilyl derivatives of some 6-hydroxy- and 3,6-dihydroxy-steroids and related compounds

The 25 e V mass spectra of the trimethylsilyl derivatives of a number of 6-hydroxy and 3,6-dihydroxy steroids together with deuterium and (18)O-labeled analogs have been examined to determine the influence of the 6-OTMS group on fragmentation patterns. Ions in the cholestane series at m/z 321 and 403 were the most characteristic ions derived from the 6-OTMS function; their relative abundances, although low in the spectra of 6-OTMS steroids themselves, were considerably elevated when a 3-OTMS or 3-oxo group was present. Similar ions were present in the spectra of androstane and pregnane derivatives. No correlation was found between the abundance of these ions and the stereochemistry at C(3), C(5), or C(6). Fragmentation mechanisms and gas chromatographic data are discussed.