77845-98-8

Upstream product

• 94783-83-2 butane-2,3-dione-mono-(O-benzyl oxime ) 
• 178753-91-8 2-[(E)-Benzyloxyimino]-propionic acid ethyl ester 
• 100-44-7 benzyl chloride 
• 2687-43-6 O-benzylhydoxylamine hydrochloride 
• 124863-30-5 2-oximinopropionic acid 
• 94783-83-2 3-(benzyloxyimino)butan-2-one 
• 622-33-3 N-benzyloxyamine 
• 113-24-6 sodium pyruvate 
• 127-17-3 2-oxo-propionic acid 
• 70771-86-7 2-benzyloxyiminopropionic acid ethyl ester 

Downstream Products

• 77846-02-7 2-[(Z)-Benzyloxyimino]-propionic acid 4-nitro-phenyl ester 
• 244009-13-0 (6R,7R)-3-Acetoxymethyl-7-{2-[(E)-benzyloxyimino]-propionylamino}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester 
• 77846-08-3 2-benzyloxyimino-propionyl chloride 
• 77846-26-5 (3R,6R)-1,4-Bis-benzyloxy-3-isopropyl-6-methyl-piperazine-2,5-dione 
• 77846-26-5 (3R,6S)-1,4-Bis-benzyloxy-3-isopropyl-6-methyl-piperazine-2,5-dione 
• 77846-23-2 (3R,6R)-1,4-Bis-benzyloxy-3,6-dimethyl-piperazine-2,5-dione 
• 77846-24-3 (3S,6R)-1,4-Bis-benzyloxy-3,6-dimethyl-piperazine-2,5-dione 
• 77846-20-9 2-[Benzyloxy-(2-benzyloxyamino-propionyl)-amino]-3-methyl-butyric acid 4-nitro-phenyl ester; hydrochloride 
• 77846-18-5 2-[Benzyloxy-(2-benzyloxyamino-propionyl)-amino]-propionic acid 4-nitro-phenyl ester; hydrochloride 
• 77846-17-4 2-[Benzyloxy-(2-benzyloxyamino-acetyl)-amino]-propionic acid 4-nitro-phenyl ester; hydrochloride 
• 77846-16-3 [Benzyloxy-(2-benzyloxyamino-propionyl)-amino]-acetic acid 4-nitro-phenyl ester; hydrochloride 
• 77846-05-0 2-Benzyloxyamino-propionic acid 4-nitro-phenyl ester; hydrochloride 
• 77846-14-1 2-(Benzyloxy-{2-[(E)-benzyloxyimino]-propionyl}-amino)-3-methyl-butyric acid 4-nitro-phenyl ester 
• 77846-12-9 2-(Benzyloxy-{2-[(E)-benzyloxyimino]-propionyl}-amino)-propionic acid 4-nitro-phenyl ester 

Relevant academic research and scientific papers

BETA-LACTAMASE INHIBITORS

Disclosed herein are α-aminoboronic acids and their derivatives which act as inhibitors of beta-lactamases. Also disclosed herein are pharmaceutical compositions comprising α-aminoboronic acids and methods of use thereof.

Synthesis and antimicrobial properties of cephalosporin derivatives substituted on the C(7) nitrogen with arylmethyloxyimino or arylmethyloxyamino alkanoyl groups

Some 7-aminocephalosporanic acid (7-ACA) derivatives substituted on the C(7) nitrogen with 2-(arylmethyloxyimino)propionyl (3a-f), 2-(arylmethyloxyamino)propionyl (4a-d) and (arylmethyloxyamino)acetyl (2a-d) moieties were synthesized by reaction of the ap

α-N-HYDROXYAMINO ACID DERIVATIVES

Reactions of organolithium reagents with glyoxylate derived oximes provided a direct route to α-N-hydroxyamino acids.The process required direct attachment of an ionizable group to the glyoxylate carbonyl to prevent competitive reactions.The procedure allowed for direct formation of the α-chiral center of the newly formed α-N-hydroxyamino acid derivative.Introduction of potential chiral auxiliaries on the oxime oxygen resulted in modest diastereoselection.In most instances, use of chiral glyoxylamides also gave low diastereoselectivity.