178753-91-8Relevant academic research and scientific papers
Syntheses of 2,3-dioxoalkylphosphonates and other novel β-ketophosphonates as well as of a phosphinopyruvamide (= (alkyloxyphosphinyl)pyruvamide)
Neidlein, Richard,Feistauer, Helmut
, p. 895 - 912 (1996)
The new 3-(diethoxyphosphoryl)-2-oxopropanoates 5 and 6 and -propanamides 1-4 with various amino substituents at C(3) were prepared (Scheme 2). These compounds exist, depending on N-substitution, as pure (E)-enols (in the case of 1 and 5) or as a mixture of three tautomeric forms (in the case of 1-4 and 6). The configuration could be unambiguously assigned from the 1H-, 13C-, and 31P-NMR spectra. Phosphinopyruvamide ( = (alkyloxyphosphinyl)pyruvamide) 9 was prepared in a similar manner in spite of the instability of phosphinate-derived carbanions. Some 3-(ethoxyimino)-2-oxobutylphosphonates, 11-13 (Scheme 5), and various 3,3-dimethoxy-2-oxoalkylphosphonates, 19-23 and 26-33 (Scheme 6), were available from the reaction of lithioalkylphosphonates with 2-(ethoxyimino)propanoates and 2,2-dimethoxyalkanoates, respectively. The 3,3-dimethoxybutylphosphonates 20, and 26-30 were cleaved to give 2,3-dioxobutylphosphonates 34-39 (Scheme 6). This method provides easy access to a new class of potentially pharmaceutically useful compounds.
1- And 2-Azetines via Visible Light-Mediated [2 + 2]-Cycloadditions of Alkynes and Oximes
Wearing, Emily R.,Blackmun, Dominique E.,Becker, Marc R.,Schindler, Corinna S.
supporting information, p. 16235 - 16242 (2021/10/20)
Azetines, four-membered unsaturated nitrogen-containing heterocycles, hold great potential for drug design and development but remain underexplored due to challenges associated with their synthesis. We report an efficient, visible light-mediated approach
N-(Aroyl)-N-(arylmethyloxy)-α-alanines: Selective inhibitors of aldose reductase
Nencetti, Susanna,La Motta, Concettina,Rossello, Armando,Sartini, Stefania,Nuti, Elisa,Ciccone, Lidia,Orlandini, Elisabetta
, p. 3068 - 3076 (2017/05/25)
Aldose reductase (ALR2), a NADPH-dependent reductase, is the first and rate-limiting enzyme of the polyol pathway of glucose metabolism and is implicated in the pathogenesis of secondary diabetic complications. In the last decades, this enzyme has been ta
Synthesis and antimicrobial properties of cephalosporin derivatives substituted on the C(7) nitrogen with arylmethyloxyimino or arylmethyloxyamino alkanoyl groups
Gentili, Daniela,Macchia, Marco,Menchini, Elisabetta,Nencetti, Susanna,Orlandini, Elisabetta,Rossello, Armando,Broccali, Giampietro,Limonta, Donatella
, p. 224 - 231 (2007/10/03)
Some 7-aminocephalosporanic acid (7-ACA) derivatives substituted on the C(7) nitrogen with 2-(arylmethyloxyimino)propionyl (3a-f), 2-(arylmethyloxyamino)propionyl (4a-d) and (arylmethyloxyamino)acetyl (2a-d) moieties were synthesized by reaction of the ap
