77856-02-1Relevant academic research and scientific papers
A SIMPLE STRATEGY FOR CHANGING THE REGIOSELECTIVITY OF GLYCOSIDASE-CATALYSED FORMATION OF DISACCHARIDES
Nilsson, Kurt G. I.
, p. 95 - 104 (1987)
The regioselectivity of glycosidase-catalysed formation of disaccharides can be changed by using α- or β-glycosyl acceptors with various aglycons.The preponderant formation of other than (1->6) linkages can be effected with glycosidases which normally give (1->6) linkages.Thus, an α-D-galactosidase can be induced to catalyse the formation mainly of α-(1->2)-, α-(1->3)-, or α-(1->6)-linked digalctosides.Both the structure of the aglycon and the configuration of the glycosidic linkage can have a pronounced influence on the regioselectivity of disaccharide formation.Enzymic syntheses, in yields of 20-30percent, are described of α-D-Galp-(1->3)-α-D-Galp-OMe, β-D-Galp-(1->3)-β-D-Galp-OMe, β-D-Galp-(1->6)-α-D-Galp-OMe, α-D-Manp-(1->2)-α-D-Manp-OMe, α-D-Manp-(1->6)-α-D-Manp-OMe, α-D-Galp-(1->2)-α-D-Galp-OPhNO2-o, α-D-Galp-(1->3)-α-D-Galp-OPhNO2-p, α-D-Manp-(1->2)-α-D-Manp-OPhNO2-p, and α-D-Manp-(1->2)-α-D-Manp-(1->2)-α-D-Manp-OMe.Soluble and immobilised enzymes have been used.
Creation of an α-mannosynthase from a broad glycosidase scaffold
Yamamoto, Keisuke,Davis, Benjamin G.
supporting information; experimental part, p. 7449 - 7453 (2012/09/21)
α-Mannosides made easy: Mutation of a family-GH31 α-glucosidase that displays plasticity to alterations at the 2-OH position of donor substrates created an efficient α-mannoside-synthesizing biocatalyst. A simple fluoride donor reagent was used for the synthesis of a range of mono-α-mannosylated conjugates using the α-mannosynthase displaying low (unwanted) oligomerization activity. Copyright
p-NITROPHENYL 2-, AND 3-O-α-D-MANNOPYRANOSYL-α-D-MANNOPYRANOSIDE
Ekborg, Goeran,Glaudemans, Cornelis P. J.
, p. 83 - 88 (2007/10/02)
p-Nitrophenyl 3- and 2-O-benzoyl-4,6-O-benzylidene-α-D-mannopyranoside were each condensed with 2,3,4,6-tetra-O-benzoyl-α-D-mannopyranosyl bromide, and the products were deprotected, to yield, respectively, p-nitrophenyl 2- and 3-O-mannopyranosyl-α-D-mann
Synthesis of Disaccharides Containing β-D-Mannopyranosyl Groups
Garegg, Per J.,Iversen, Tommy,Johansson, Rolf
, p. 505 - 508 (2007/10/02)
An efficient synthesis of β-D-mannopyranosides is described.D-Mannose is converted by acetalyzation under kinetic control into crystalline 2,3:4,6-di-O-cyclohexylidene-α-D-mannopyranose.Reaction of the acetal with methanesulfonyl chloride in the presence
