77857-35-3

Upstream product

• 63-91-2 L-phenylalanine 
• 3182-95-4 L-Phenylalaninol 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 108-94-1 cyclohexanone 
• 64715-80-6 (S)-1-benzyl-2-methoxyethylamine 

Downstream Products

• 6126-53-0 (S)-2-acetonylcyclohexanone 
• 77857-40-0 (R)-2-(2-oxopropyl)cyclohexan-1-one 
• 1029407-85-9 (S)-2-(2-methoxyethyl)cyclohexanone 
• 77857-41-1 (R)-(+)-2-(2-methoxyethyl)cyclohexanone 
• 766-42-7 cis-2,6-dimethylcyclohexanone 
• 77882-09-8 (2S,6S)-(+)-2,6-dimethylcyclohexanone 
• 22554-27-4 (S)-2-methylcyclohexanone 
• 22554-29-6 (R)-2-methylcyclohexanone 
• 149056-85-9 (S)-2-[4-((1R)-2-hydroxycyclohexylmethyl)phenyl]propionic acid 
• 149056-83-7 (S)-2-[4-((1R,2S)-2-hydroxycyclohexylmethyl)phenyl]propionic acid 
• 1333080-47-9 C₁₆H₂₀O₃ 
• 1333080-46-8 (R)-2-[4-((S)-2-hydroxy-1-methylethyl)benzyl]cyclohexanone 
• 1333080-44-6 C₃₂H₄₀O₂Si 
• 134005-44-0 (2R,3R,6R)-6-(2-Benzyloxy-ethyl)-2,3-dimethyl-1,4-dioxa-spiro[4.5]decane 

Relevant academic research and scientific papers

Asymmetric synthesis of the active form of loxoprofen and its analogue

The asymmetric synthesis of the active form of the antiinflammatory drug loxoprofen has been reported in this article. Enzymatic kinetic resolution/racemization of a substituted homo-benzylic primary alcohol with lipase-PS, asymmetric alkylation of cyclic ketones using either Enders' or Meyers' strategy followed by a stereoselective biocatalytic reduction of carbonyl group are the key reactions employed successfully to achieve the target molecule and one of its analogue.