77862-95-4

Basic information

• Product Name: 1H-IMidazo[4,5-b]pyridine-6-carboxylic acid, Methyl ester
• Synonyms: 1H-IMidazo[4,5-b]pyridine-6-carboxylic acid, Methyl ester;Methyl 1H-iMidazo[4,5-b]pyridine-6-carboxylate;ethyl 3H-imidazo[4,5-b]pyridine-6-carboxylate
• CAS NO: 77862-95-4
• Molecular Formula: C8H7N3O2
• Molecular Weight: 177.16008
• Mol File: 77862-95-4.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1H-IMidazo[4,5-b]pyridine-6-carboxylic acid, Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-IMidazo[4,5-b]pyridine-6-carboxylic acid, Methyl ester(77862-95-4)
• EPA Substance Registry System: 1H-IMidazo[4,5-b]pyridine-6-carboxylic acid, Methyl ester(77862-95-4)

Safety Data

• Hazardous Substances Data: 77862-95-4(Hazardous Substances Data)

Usage

General Description

1H-Imidazo[4,5-b]pyridine-6-carboxylic acid, methyl ester is a chemical compound with the molecular formula C10H8N2O2. It is a methyl ester derivative of 1H-Imidazo[4,5-b]pyridine-6-carboxylic acid, which is a heterocyclic compound containing an imidazole ring fused to a pyridine ring. This chemical is commonly used as a building block in organic synthesis and pharmaceutical research. It has potential biological activities and is being explored for its potential as a drug candidate. Additionally, it can also be used as a reagent in chemical reactions for the production of various other compounds.

Upstream product

• 122-51-0 orthoformic acid triethyl ester 
• 104685-76-9 5,6-diamino-nicotinic acid methyl ester 
• 64-18-6 formic acid 
• 104685-75-8 methyl 2-amino-3-nitropyridine-5-carboxylate 
• 67-56-1 methanol 
• 201230-82-2 carbon monoxide 
• 28279-49-4 6-bromo-3H-imidazo[4,5-b]pyridine 
• 38875-53-5 5-bromo-pyridine-2,3-diamine 

Relevant articles and documents

Convenient synthesis of imidazo[1,5-a]pyrimidine derivatives and their unusual recyclization into 3H-imidazo[4,5-b]pyridine derivatives

[Figure not available: see fulltext.] New derivatives of imidazo[1,5-a]pyrimidine have been synthesized by cyclization of in situ generated 1H-imidazol-4(5)-amine with 1,3-diketones or malondialdehyde derivatives. Utilization of asymmetrical 1,3-diketones leads to the formation of a mixture of regioisomers. The discovered conversion of imidazo[1,5-a]pyrimidine core into 3H-imidazo[4,5-b]pyridine that takes place only under acidic conditions can be considered as a new version of Dimroth rearrangement involving cleavage of C–N bond and formation of C–C bond.

Thrombin inhibitors

Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: or a pharmaceutically acceptable salt thereof, wherein b is NY or O; c is CY2or N; d is CY3or N; e is CY4or N; f is CY5or N; g is CY6or N; Y4, Y5, and Y6are independently hydrogen, C1-4alkyl, or halogen; Y1and Y2are independently hydrogen, C1-4alkyl, C3-7cycloalkyl, halogen, NH2, OH or C1-4alkoxy, and Y3is hydrogen, C1-4alkyl, C3-7cycloalkyl, halogen, —CN, NH2, OH or C1-4alkoxy; A is and W, W1, R1, R3, R4, R5, X and Z are defined in the specification.