77902-92-2

Upstream product

• 77902-87-5 2,2-dimethyl-1-(pyrrolidin-1-yl)propane-1-thione 
• 77902-89-7 benzyl <(trifluoromethyl)sulfonyloxy>acetate 
• 17094-34-7 ethyl pivaloylacetate 
• 100-51-6 benzyl alcohol 
• 3282-30-2 pivaloyl chloride 
• 30379-58-9 benzyl glycolate 
• 55107-14-7 Methyl 4,4-dimethyl-3-oxopentanoate 

Downstream Products

• 188526-16-1 benzyl 5-t-butyl-1,3-dioxolene-2-one-4-carboxylate 
• 188526-15-0 benzyl 4,4-dimethyl-2-hydroxy-3-oxopentanoate 
• 188526-14-9 [1-(benzyloxy)-4,4-dimethyl-1,3-dioxopentan-2-yl]diazen-2-ium-1-ide 

Relevant academic research and scientific papers

COMPOUNDS HAVING TAFIa INHIBITORY ACTIVITY

The present invention provides compounds having superior TAFIa inhibitory activity. They are dihydroimidazoquinoline compounds represented by the following formula (I) or pharmaceutically acceptable salts thereof: (I) wherein R is a hydrogen atom or a Cs

Bismuth(III) chloride-catalyzed highly efficient transesterification of β-keto esters

Bismuth(III) chloride was found to be an efficient catalyst for the transesterification of a variety of β-keto esters with a wide range of alcohols to afford transesterified products in good to high yields in short reaction times (see Table). Copyright

HETEROCYCLIC ANTI-VIRAL COMPOUNDS COMPRISING METABOLIZABLE MOIETIES AND THEIR USES

The present invention relates to substituted prodrug and compositions thereof useful for treating or preventing Hepatitis C virus (HCV) infections. In particular, the present invention relates to prodrugs of substituted diphenyl-, diheteroaryl- and mixed phenyl heteroaryl substituted five-membered heterocycle compounds, compositions comprising the compounds and the use of such compounds and compositions to inhibit HCV replication and/or proliferation as a therapeutic approach towards the treatment and/or prevention of HCV infections in humans and animals.

A general synthesis of dioxolenone prodrug moieties

A general method for the synthesis of dioxolenone prodrug moieties from appropriately substituted β-ketoesters is described. This novel and versatile sequence allows for the synthesis of alkyl- or aryl-substituted dioxolenone alcohols 8 or bromides 9. Coupling of the bromides 9 to prepare bis-dioxolenone phosphonate prodrug esters is also presented.

Process for the production of 3-oxocarboxylic acid esters

3-Oxocarboxylic acid esters are produced by acylation of the magnesium enolates of acetoacetic acid esters with carboxylic acid chlorides and cleavage of the acetyl group from the acylacetoacetic acid esters formed as the intermediate product. The yields and purity of the products are considerably improved by adding a tertiary amine during the acylation.

Versatile β-Keto Ester and β-Keto Nitrile Synthesis through Sulfide Contraction.

A versatile and efficient synthesis for various β-keto esters, including those which are α substituted, is described.The α-thio iminium salt prepared from a thioamide and a primary or secondary alkylating agent is subjected to sulfur extrusion upon addition of base and a phosphine thiophile, and the result is an enamino ester which may be hydrolyzed to the desired β-keto ester.The method is also applicable to the preparation of various substituted β-keto nitriles.