779341-05-8

Upstream product

• 96568-05-7 2,6-dichloro-α-(ethoxymethylene)-5-fluoro-β-oxo-3-pyridinepropanoic acid ethyl ester 
• 635309-38-5 1-(2,4-dimethoxybenzyl)-6-fluoro-4-oxo-7-(pyrrolidin-1-yl)-1,4-dihydro[1,8]naphthyridine-3-carboxylic acid ethyl ester 
• 779337-66-5 1-(2,4-dimethoxybenzyl)-6-fluoro-4-oxo-7-pyrrolidin-1-yl-1,4-dihydro-1,8-naphthyridine-3-carboxylic Acid 
• 110286-39-0 (Z)-2-(2,6-Dichloro-5-fluoro-pyridine-3-carbonyl)-3-(2,4-dimethoxy-benzylamino)-acrylic acid ethyl ester 
• 110286-57-2 7-chloro-1-(2,4-dimethoxybenzyl)-6-fluoro-4-oxo-1,4-dihydro[1,8]naphthyridine-3-carboxylic acid ethyl ester 
• 20781-20-8 2,4-Dimethoxybenzylamine 
• 779339-62-7 1-(2,4-dimethoxy-benzyl)-6-fluoro-4-oxo-7-pyrrolidin-1-yl-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid methoxy-methyl-amide 

Downstream Products

• 779343-24-7 1-(2,4-dimethoxy-benzyl)-3-[(2-dimethylamino-ethylamino)-methyl]-6-fluoro-7-pyrrolidin-1-yl-1H-[1,8]naphthyridin-4-one 
• 779343-22-5 1-(2,4-dimethoxy-benzyl)-6-fluoro-3-phenylaminomethyl-7-pyrrolidin-1-yl-1H-[1,8]naphthyridin-4-one 
• 779343-11-2 1-(2,4-dimethoxy-benzyl)-6-fluoro-3-hydroxymethyl-7-pyrrolidin-1-yl-1H-[1,8]naphthyridin-4-one 
• 779343-23-6 3-(benzylamino-methyl)-1-(2,4-dimethoxy-benzyl)-6-fluoro-7-pyrrolidin-1-yl-1H-[1,8]naphthyridin-4-one 

Relevant academic research and scientific papers

Novel inhibitors of bacterial protein synthesis: Structure-activity relationships for 1,8-naphthyridine derivatives incorporating position 3 and 4 variants

Structure-activity relationships for a recently discovered novel ribosome inhibitor (NRI) class of antibacterials were investigated. Preliminary efforts to optimize protein synthesis inhibitory activity of the series through modification of positions 3 an