635309-38-5

Upstream product

• 123-75-1 pyrrolidine 
• 110286-57-2 7-chloro-1-(2,4-dimethoxybenzyl)-6-fluoro-4-oxo-1,4-dihydro[1,8]naphthyridine-3-carboxylic acid ethyl ester 
• 96568-04-6 ethyl 3-(2,6-dichloro-5-fluoropyridin-3-yl)-3-oxopropanoate 
• 96568-05-7 2,6-dichloro-α-(ethoxymethylene)-5-fluoro-β-oxo-3-pyridinepropanoic acid ethyl ester 
• 20781-20-8 2,4-Dimethoxybenzylamine 
• 110286-39-0 (Z)-2-(2,6-Dichloro-5-fluoro-pyridine-3-carbonyl)-3-(2,4-dimethoxy-benzylamino)-acrylic acid ethyl ester 

Downstream Products

• 779343-23-6 3-(benzylamino-methyl)-1-(2,4-dimethoxy-benzyl)-6-fluoro-7-pyrrolidin-1-yl-1H-[1,8]naphthyridin-4-one 
• 779343-22-5 1-(2,4-dimethoxy-benzyl)-6-fluoro-3-phenylaminomethyl-7-pyrrolidin-1-yl-1H-[1,8]naphthyridin-4-one 
• 779343-24-7 1-(2,4-dimethoxy-benzyl)-3-[(2-dimethylamino-ethylamino)-methyl]-6-fluoro-7-pyrrolidin-1-yl-1H-[1,8]naphthyridin-4-one 
• 779339-62-7 1-(2,4-dimethoxy-benzyl)-6-fluoro-4-oxo-7-pyrrolidin-1-yl-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid methoxy-methyl-amide 
• 779343-11-2 1-(2,4-dimethoxy-benzyl)-6-fluoro-3-hydroxymethyl-7-pyrrolidin-1-yl-1H-[1,8]naphthyridin-4-one 
• 779341-05-8 1-(2,4-dimethoxy-benzyl)-6-fluoro-4-oxo-7-pyrrolidin-1-yl-1,4-dihydro-[1,8]naphthyridine-3-carbaldehyde 
• 779337-66-5 1-(2,4-dimethoxybenzyl)-6-fluoro-4-oxo-7-pyrrolidin-1-yl-1,4-dihydro-1,8-naphthyridine-3-carboxylic Acid 

Relevant academic research and scientific papers

Novel antibacterial class: A series of tetracyclic derivatives

We describe the synthesis and antibacterial activity of a series of tetracyclic naphthyridones. The members of this series act primarily via inhibition of bacterial translation and belong to the class of novel ribosome inhibitors (NRIs). In this paper we

Rearrangements encountered in the attempted syntheses of pyridoazepinone carboxylic acids

(Chemical equation presented) Attempts to synthesize pyridoazepinone carboxylic acids such as 33 by standard methodologies resulted exclusively in unusual and unexpected rearrangement products. Seven-membered ring formation was attempted by ring expansion

Novel inhibitors of bacterial protein synthesis: Structure-activity relationships for 1,8-naphthyridine derivatives incorporating position 3 and 4 variants

Structure-activity relationships for a recently discovered novel ribosome inhibitor (NRI) class of antibacterials were investigated. Preliminary efforts to optimize protein synthesis inhibitory activity of the series through modification of positions 3 an

Antibacterial compounds

Antibacterials having formula (I) and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and methods of prophylaxis and treatment of bacterial infections using the compounds are disclosed.