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1H-Pyrazole-4-carboxamide,3-amino-N-methyl-(9CI) is a chemical compound characterized by the molecular formula C5H7N5O. It is a pyrazole derivative featuring an amino group and a methyl group. 1H-Pyrazole-4-carboxamide,3-amino-N-methyl-(9CI) is recognized for its potential in the pharmaceutical industry, particularly in the development of innovative drugs. Its structural attributes and reactivity contribute to its value as a building block for synthesizing a range of bioactive compounds. The unique chemical structure and properties of 1H-Pyrazole-4-carboxamide,3-amino-N-methyl-(9CI) position it as a promising candidate for further exploration and advancement in medicinal chemistry.

77937-05-4

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77937-05-4 Usage

Uses

Used in Pharmaceutical Industry:
1H-Pyrazole-4-carboxamide,3-amino-N-methyl-(9CI) is utilized as a key intermediate in the synthesis of various bioactive compounds for medicinal applications. Its unique structural features and reactivity make it a valuable component in the development of new drugs with potential therapeutic benefits.
Used in Medicinal Chemistry Research:
1H-Pyrazole-4-carboxamide,3-amino-N-methyl-(9CI) serves as a promising subject for research in medicinal chemistry, where its properties and interactions can be studied to understand its potential role in drug discovery and design. The exploration of 1H-Pyrazole-4-carboxamide,3-amino-N-methyl-(9CI) may lead to the identification of novel therapeutic agents or mechanisms of action.

Check Digit Verification of cas no

The CAS Registry Mumber 77937-05-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,7,9,3 and 7 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 77937-05:
(7*7)+(6*7)+(5*9)+(4*3)+(3*7)+(2*0)+(1*5)=174
174 % 10 = 4
So 77937-05-4 is a valid CAS Registry Number.

77937-05-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-Amino-N-methyl-1H-pyrazole-4-carboxamide

1.2 Other means of identification

Product number -
Other names 5-amino-1H-pyrazole-4-carboxylic acid methylamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:77937-05-4 SDS

77937-05-4Relevant academic research and scientific papers

Synthesis and pharmacological activity of triazole derivatives inhibiting eosinophilia

Naito, Youichiro,Akahoshi, Fumihiko,Takeda, Shinji,Okada, Takehiro,Kajii, Masahiko,Nishimura, Hiroko,Sugiura, Masanori,Fukaya, Chikara,Kagitani, Yoshio

, p. 3019 - 3029 (2007/10/03)

In order to develop novel antiasthmatic agents based on a new mechanism of action, a series of 3-substituted 5-amino-1- [(methylamino)(thiocarbonyl)]-1H-1,2,4-triazole derivatives were synthesized and evaluated in a model in which eosinophilia was induced in the airway through intravenous (iv) injection of Sephadex particles on days 0, 2, and 5. After screening of several hundred derivatives, we finally identified the highly potent eosinophilia inhibitor 5-amino-3-(4-chlorophenyl)-1- [(methylamino)(thiocarbonyl)]-1H-triazole (23c, GCC-AP0341), which had ID50 values of 0.3 and 0.07 mg/kg when administered orally (os) and intraperitoneally (ip), respectively. This compound showed complete inhibition of the hypersensitivity induced by ascaris inhalation at an ip dose of 1 mg/kg as well as low toxicity, with an LD50 value of >2.0 g/kg in mice. Extensive study of its mechanism of action revealed that 23c inhibited eosinophil survival induced by interleukin-5 (IL-5), but had little or no effect on leukotriene D4 (LTD4) or platelet-activating factor (PAF)- induced responses. Taken together, these results suggest 23c as a novel candidate for the treatment of chronic asthma. Further studies are now underway.

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