77971-34-7

Upstream product

• 77971-33-6 2-phenyl-1,3,2-oxazaphospholidine-2-thione 
• 79756-20-0 ((1S,2R)-2-Bromo-1-methyl-2-phenyl-ethyl)-methyl-amine; hydrochloride 
• 3497-00-5 phenylthiophosphonic acid dichloride 
• 50-98-6 ephedrine hydrochloride 
• 90-81-3 (S,S)-(+)-pseudoephedrine 

Downstream Products

• 6389-79-3 (+)-(R)_p methyl methylphenylphosphinate 
• 2240-41-7 dimethyl phenylphosphonate 
• 77971-35-8 (R)-Phenyl-phosphonothioic acid O-methyl ester S-((1S,2S)-2-methylamino-1-phenyl-propyl) ester 
• 79756-21-1 (R)-Phenyl-phosphonothioic acid O-ethyl ester S-((1S,2S)-2-methylamino-1-phenyl-propyl) ester; hydrochloride 

Relevant academic research and scientific papers

1,3,2-Thiazaphospholidin-2-ones Derived From Ephedrine. Preparation and Stereochemistry of Ring-opening Reactions

1,3,2-thiazaphospholidin-2-ones are prepared by rearrangement of the corresponding 1,3,2-oxazaphospholidine-2-thiones.In both the phosphono- and phosphoro-series treatment with alkoxide results in P-N bond cleavage with inversion of configuration, while treatment with Grignard reagents results in P-S bond cleavage with retention of configuration.The products are consistent with a mechanism which involves initial nucleophilic attack opposite endocyclic nitrogen.

THE PREPARATION AND SOME REACTIONS OF 1,3,2-THIAZAPHOSPHOLIDINE-2-ONES

1,3,2-Thiazaphospholidine-2-ones have been prepared by rearrangement of the corresponding 1,3,2-phospholidine-2-thiones.The stereochemical course of ring opening reactions has been investigated.