77971-35-8

Upstream product

• 67-56-1 methanol 
• 77971-34-7 (2S,4S,5S)-2,5-diphenyl-3,4-dimethyl-1,3,2-thiazaphospholidin-2-one 
• 124-41-4 sodium methylate 
• 90-81-3 (S,S)-(+)-pseudoephedrine 
• 3497-00-5 phenylthiophosphonic acid dichloride 
• 77971-33-6 2-phenyl-1,3,2-oxazaphospholidine-2-thione 

Relevant academic research and scientific papers

1,3,2-Thiazaphospholidin-2-ones Derived From Ephedrine. Preparation and Stereochemistry of Ring-opening Reactions

1,3,2-thiazaphospholidin-2-ones are prepared by rearrangement of the corresponding 1,3,2-oxazaphospholidine-2-thiones.In both the phosphono- and phosphoro-series treatment with alkoxide results in P-N bond cleavage with inversion of configuration, while treatment with Grignard reagents results in P-S bond cleavage with retention of configuration.The products are consistent with a mechanism which involves initial nucleophilic attack opposite endocyclic nitrogen.

THE PREPARATION AND SOME REACTIONS OF 1,3,2-THIAZAPHOSPHOLIDINE-2-ONES

1,3,2-Thiazaphospholidine-2-ones have been prepared by rearrangement of the corresponding 1,3,2-phospholidine-2-thiones.The stereochemical course of ring opening reactions has been investigated.