77978-74-6

Usage

Uses

Used in Pharmaceutical Industry:
METHYL 4-(2-METHOXY-2-OXOETHYL)-2-METHYL-5-OXO-4,5-DIHYDRO-1H-PYRROLE-3-CARBOXYLATE is used as a chemical precursor for the synthesis of various drugs, playing a crucial role in the development of new pharmaceuticals.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, METHYL 4-(2-METHOXY-2-OXOETHYL)-2-METHYL-5-OXO-4,5-DIHYDRO-1H-PYRROLE-3-CARBOXYLATE is utilized for its potential to contribute to the creation of compounds with medicinal properties, thereby advancing the discovery of novel therapeutic agents.
Used in Drug Discovery:
METHYL 4-(2-METHOXY-2-OXOETHYL)-2-METHYL-5-OXO-4,5-DIHYDRO-1H-PYRROLE-3-CARBOXYLATE is employed in drug discovery processes to explore its potential in forming the basis of new drug candidates, thanks to its unique structural and chemical characteristics.

InChI:InChI=1/C10H13NO5/c1-5-8(10(14)16-3)6(9(13)11-5)4-7(12)15-2/h6H,4H2,1-3H3,(H,11,13)

Upstream product

• 67-56-1 methanol 
• 77978-73-5 4-Methoxycarbonyl-5-methyl-2-oxo-4-pyrrolin-3-essigsaeure 
• 21731-17-9 methyl 3-aminocrotonate 

Downstream Products

• 77978-86-0 2-Chlor-4-methoxycarbonyl-5-methyl-3-pyrrolessigsaeure-methylester 
• 77978-96-2 9-Benzoyloxy-3,7-dimethoxycarbonyl-1-ethoxy-10H-dipyrromethen-2,8-diessigsaeure-dimethylester 
• 77978-78-0 5-Dibenzylaminomethylen-4-methoxycarbonyl-2-oxo-3-pyrrolin-3-essigsaeure-methylester 
• 77978-79-1 4-Methoxycarbonyl-2-oxo-5-phenylhydrazonomethyl-4-pyrrolin-3-essigsaeure-methylester 
• 77978-85-9 2-Acetoxy-4-methoxycarbonyl-5-methyl-3-pyrrolessigsaeure-methylester 

Relevant academic research and scientific papers

Thionations using a P4S10-pyridine complex in solvents such as acetonitrile and dimethyl sulfone

Tetraphosphorus decasulfide (P4S10) in pyridine has been used as a thionating agent for a long period of time. The moisture-sensitive reagent has now been isolated in crystalline form, and the detailed structure has been determined by X-ray crystallography. The thionating power of this storable reagent has been studied and transferred to solvents such as acetonitrile in which it has proven to be synthetically useful and exceptionally selective. Its properties have been compared with the so-called Lawesson reagent (LR). Particularly interesting are the results from thionations at relatively high temperatures (165 °C) in dimethyl sulfone as solvent. Under these conditions, for instance, acridone and 3-acetylindole could quickly be transformed to the corresponding thionated derivatives. Glycylglycine similarly gave piperazinedithione. At these temperatures, LR is inefficient due to rapid decomposition. The thionated products are generally cleaner and more easy to obtain because in the crystalline reagent, impurities which invariably are present in the conventional reagents, P4S 10 in pyridine or LR, have been removed. 2011 American Chemical Society.

Pyrrolinones, IV Pyrrolin-2-ones with Electron Attracting Substituents in the &β-Positions

The pyrrolinones 3-7, synthesized from maleic acid derivatives and enamines and also their reaction products 8-24 are described.By comparison with the classic-type dipyrromethenes 26, 30 and 31 the dipyrromethenes 27 as well as 25, 28 and 29 are shown to exist as lactams (neo-type dipyrromethenes).In basic solution 27 exhibits a deep blue colour which is unusual for dipyrromethenes.