77995-40-5

Upstream product

• 77995-35-8 4-Methyl-7,8,9,10-tetrahydro-6-thia-1,2,3a,5-tetraaza-cyclopenta[c]fluorene 
• 122-51-0 orthoformic acid triethyl ester 
• 113246-92-7 2-Amino-3-(1H-1,2,4-triazol-3-yl)-4,5,6,7-tetrahydrobenzothiophene 
• 75-05-8 acetonitrile 
• 58125-46-5 8,9,10,11-tetrahydro-benzo[4,5]thieno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine 
• 178685-48-8 N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)acetimidic acid ethyl ester 
• 77995-54-1 4-hydrazinyl-2-methyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine 
• 4651-91-6 3-cyano-2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene 
• 64-18-6 formic acid 

Downstream Products

• 101130-25-0 4-[(E)-2-(4-Nitro-phenyl)-vinyl]-7,8,9,10-tetrahydro-6-thia-1,3,3a,5-tetraaza-cyclopenta[c]fluorene 
• 101130-23-8 4-((E)-Styryl)-7,8,9,10-tetrahydro-6-thia-1,3,3a,5-tetraaza-cyclopenta[c]fluorene 
• 101130-26-1 4-[(E)-2-(4-Methoxy-phenyl)-vinyl]-7,8,9,10-tetrahydro-6-thia-1,3,3a,5-tetraaza-cyclopenta[c]fluorene 

Relevant academic research and scientific papers

Synthesis and pharmacological evaluation of novel thienopyrimidine and triazolothienopyrimidine derivatives

Novel tricyclic thienopyrimidines (2, 3, 5, 8) and triazole-fused tetracyclic thienopyrimidines (6a-c and 9a-c) were synthesized from the precursor 2-Amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carbonitrile (1). The structures of newly synthesized compounds were established by spectral and analytical data. The title compounds were screened for analgesic, anti-inflammatory, ulcerogenicity index, and antibacterial activities. Test compounds exhibited significant activity, the compounds (6a-c) and (9a-c) showed more potent analgesic activity, and the compounds (6c) and (9c) showed more potent anti-inflammatory activity than the reference standard Diclofenac Sodium. All the synthesized compounds exhibited remarkable antibacterial activity.

Studies on the Synthesis and Interconversion of Isomeric Triazolothienopyrimidines. Part III. Cyclization Reactions of 2-Amino-3-(1H-1,2,4-triazol-3-yl)thiophenes

Isolation of 2-amino-3-(1H-1,2,4-triazol-3-yl)thiophenes in the hydrolytic cleavage reactions of isomeric triazolothienopyrimidines is reported.The 2-amino-3-triazolylthiophenes on reaction with one carbon donors were found to cyclize to 1,2,4-triazolothienopyrimidines, exclusively.

Studies in the Synthesis and Interconversion of Isomeric Triazolothienopyrimidines

4-Hydrazinothienopyrimidines were cyclized with triethyl orthoformate and formic acid to give 1,2,4-triazolothienopyrimidines and 1,2,4-triazolothienopyrimidines depending on the reaction conditions employed.