77995-40-5Relevant academic research and scientific papers
Synthesis and pharmacological evaluation of novel thienopyrimidine and triazolothienopyrimidine derivatives
Mulla, Jameel Ahmed S.,Khazi, Mohammed Iqbal A.,Panchamukhi, Shridhar I.,Gong, Young-Dae,Khazi, Imtiyaz Ahmed M.
, p. 3235 - 3243 (2014/05/06)
Novel tricyclic thienopyrimidines (2, 3, 5, 8) and triazole-fused tetracyclic thienopyrimidines (6a-c and 9a-c) were synthesized from the precursor 2-Amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carbonitrile (1). The structures of newly synthesized compounds were established by spectral and analytical data. The title compounds were screened for analgesic, anti-inflammatory, ulcerogenicity index, and antibacterial activities. Test compounds exhibited significant activity, the compounds (6a-c) and (9a-c) showed more potent analgesic activity, and the compounds (6c) and (9c) showed more potent anti-inflammatory activity than the reference standard Diclofenac Sodium. All the synthesized compounds exhibited remarkable antibacterial activity.
Studies on the Synthesis and Interconversion of Isomeric Triazolothienopyrimidines. Part III. Cyclization Reactions of 2-Amino-3-(1H-1,2,4-triazol-3-yl)thiophenes
Shishoo, C. J.,Devani, M. B.,Ullas, G. V.,Ananthan, S.,Bhadti, V. S.
, p. 1125 - 1131 (2007/10/02)
Isolation of 2-amino-3-(1H-1,2,4-triazol-3-yl)thiophenes in the hydrolytic cleavage reactions of isomeric triazolothienopyrimidines is reported.The 2-amino-3-triazolylthiophenes on reaction with one carbon donors were found to cyclize to 1,2,4-triazolothienopyrimidines, exclusively.
Studies in the Synthesis and Interconversion of Isomeric Triazolothienopyrimidines
Shishoo, C. J.,Devani, M. B.,Ullas, G. V.,Anathan, S.,Bhadti, V. S.
, p. 43 - 46 (2007/10/02)
4-Hydrazinothienopyrimidines were cyclized with triethyl orthoformate and formic acid to give 1,2,4-triazolothienopyrimidines and 1,2,4-triazolothienopyrimidines depending on the reaction conditions employed.
