78-53-5 Usage
Chemical Properties
Amiton is a liquid organophosphate.
Uses
Insecticide.
General Description
Liquid. Used as an acaricide and insecticide.
Reactivity Profile
Organothiophosphates, such as S-[2-(Diethylamino)ethyl]O，O-diethylphosphorothioate, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.
Hazard
Cholinesterase inhibitor. Use may be
restricted.
Health Hazard
Different sources of media describe the Health Hazard of 78-53-5 differently. You can refer to the following data:
1. S-[2-(Diethylamino)ethyl]O，O-diethylphosphorothioate is highly toxic orally. It is a cholinesterase inhibitor.
2. One of the most toxic organophosphorusinsecticides; highly toxic by oral route;effects are cumulative; toxic symptoms aresimilar to those of other cholinesteraseinhibitors and include nausea, vomiting, diar-rhea, excessive salivation, blurred vision andpain in eye muscle, convulsion, coma, andrespiratory failure; probable lethal dose isestimated to be 5–10 g for adult humans.
Fire Hazard
When heated to decomposition, can emit toxic fumes of oxides of nitrogen, phosphorus, and sulfur. (Non-Specific -- Organophosphorus Pesticide, Liquid, n.o.s.) Container may explode in heat of fire. Fire may produce irritating or poisonous gases. Runoff from fire control water may give off poisonous gases. Runoff from fire control or dilution water may cause pollution. Avoid extreme heat.
Potential Exposure
Amiton is used as an acaricide and an
insecticide; exposure may occur in manufacture and in
application and use. VG has been used as a military nerve
agent.
Shipping
UN3018 Organophosphorus pesticides, liquid,
toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous material.
Purification Methods
Recrystallise it from isopropanol/diethyl ether. [Ailman & Magee in Organo Phosphorus Compound (Kosolapoff & Maier eds) Wiley Vol 7 pp 487-871 1976.] Diethylmethylsilane [760 -32 -7] M 102.3, b 78.4o/760mm, 77.2 -77.6o/atm, d 4 0.71. Fractionally distil it through a ca 20-plate column, and the fraction boiling within a range of less than 0.5o is collected. It is a flammable irritating liquid. [Price J Am Chem Soc 69 2600 1947, Beilstein 4 III 1847.]
Incompatibilities
Contact with strong oxidizers may cause
release of toxic phosphorus oxides. Incompatible with oxidizers
(chlorates, nitrates, peroxides, permanganates, perchlorates,
chlorine, bromine, fluorine, etc.); contact may
cause fires or explosions. Keep away from alkaline materials,
strong bases, strong acids, oxoacids, epoxides.
Organophosphates, in the presence of strong reducing
agents such as hydrides, may form highly toxic and flammable
phosphine gas. Keep away from alkaline materials.
Waste Disposal
Use a licensed professional
waste disposal service to dispose of this material. All federal,
state, and local environmental regulations must be
observed. High-temperature incineration. Hydrolysis may
also be used. In accordance with 40CFR165, follow
recommendations for the disposal of pesticides and pesticide
containers. Must be disposed properly by following
package label directions or by contacting your local or federal
environmental control agency, or by contacting your
regional EPA office.
Check Digit Verification of cas no
The CAS Registry Mumber 78-53-5 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 7 and 8 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 78-53:
(4*7)+(3*8)+(2*5)+(1*3)=65
65 % 10 = 5
So 78-53-5 is a valid CAS Registry Number.
InChI:InChI=1/C10H24NO3PS/c1-5-10(6-2,9-11)16-15(12,13-7-3)14-8-4/h5-9,11H2,1-4H3
78-53-5Relevant academic research and scientific papers
Application of the Transpiration Method to Determine the Vapor Pressure and Related Physico-Chemical Data of Low Volatile, Thermolabile, and Toxic Organo(thio)phosphates
Althoff, Marc A.,Grieger, Kathrin,H?rtel, Martin A. C.,Karaghiosoff, Konstantin L.,Klap?tke, Thomas M.,Metzulat, Manfred
, p. 2603 - 2609 (2017/05/29)
The present work represents the most recent study on the physico-chemical properties of the organophosphate compound class being directly related to the Chemical Weapons Convention (CWC). This compound class is of great importance in the ongoing conflict in Syria. Here, the vapor pressure of the deadly organo(thio)phosphate Amiton and seven of its derivatives was investigated. These medium to low volatile analytes pose a potential threat toward human life by inhalation or direct contact with the skin at very low doses. Therefore, the vapor pressures in ambient temperature regimes were measured by utilizing the transpiration method to determine the saturation vapor pressure psat and the enthalpy of vaporization ΔlgHm° at 298.15 K. We also successfully applied the transpiration method for the examination of thermolabile compounds. In particular, five of the molecules can undergo a thiono-thiolo rearrangement at elevated temperatures within a couple of hours and thus could possibly alter in the course of the experiment. In addition we demonstrate that the concentration under diffusion conditions, cdif, is a useful parameter for the choice of suitable gas phase detection equipment for Amiton and its derivatives, because it can be directly compared with the limit of detection LOD [ng L-1] of the device used. Finally, we proved the transpiration method to be applicable for the investigation of toxic and also high boiling and even thermolabile chemicals in general.
VARIANTS OF PHOSPHOTRIESTERASE FOR THE HYDROLYSIS AND DETOXIFICATION OF NERVE AGENTS
-
, (2016/05/24)
Variants of phosphotriesterase have been created that exhibit enhanced hydrolysis of V-type and G-type nerve agents over wild-type phosphotriesterase. V- and G-type nerve agents have an SP and RP enantiomer. The SP enantiomers are more toxic. V-type nerve
Variants of Phosphotriesterase for the Enhanced Detoxification of the Chemical Warfare Agent VR
Bigley, Andrew N.,Mabanglo, Mark F.,Harvey, Steven P.,Raushel, Frank M.
, p. 5502 - 5512 (2015/09/15)
The V-type organophosphorus nerve agents are among the most hazardous compounds known. Previous efforts to evolve the bacterial enzyme phosphotriesterase (PTE) for the hydrolytic decontamination of VX resulted in the identification of the variant L7ep-3a,
SYNTHESIS OF S-DIALKYLAMINO THIOPHOSPHATES
Petrov, K. A.,Rudnev, G. V.,Sorokin, V. D.
, p. 1012 - 1014 (2007/10/02)
O,O-Dialkyl S-(2-dialkylaminoethyl) thiophosphates are obtained by the reaction of dialkylamino sulfenyl chlorides, sulfenamides, thiobisamines, and amino disulfides with neutral and acidic alkyl phosphites; in the case of sulfenamides the synthesis is carried out under acid-catalysis conditions using zinc chloride.N,N-Dimethylthiobisamine reacts with the neutral phosphite to give O,O-diethyl S-dimethylamino thiophosphate, while the reaction of the amino disulfide with sodium diethyl phosphite leads to 2-diethylaminoethyl ethyl sulfide.
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