100-38-9Relevant academic research and scientific papers
Rapid Synthesis of a Lipocationic Polyester Library via Ring-Opening Polymerization of Functional Valerolactones for Efficacious siRNA Delivery
Hao, Jing,Kos, Petra,Zhou, Kejin,Miller, Jason B.,Xue, Lian,Yan, Yunfeng,Xiong, Hu,Elkassih, Sussana,Siegwart, Daniel J.
, p. 9206 - 9209 (2015)
The ability to control chemical functionality is an exciting feature of modern polymer science that enables precise design of drug delivery systems. Ring-opening polymerization of functional monomers has emerged as a versatile method to prepare clinically translatable degradable polyesters.1 A variety of functional groups have been introduced into lactones; however, the direct polymerization of tertiary amine functionalized cyclic esters has remained elusive. We report a strategy that enabled the rapid synthesis of >130 lipocationic polyesters directly from functional monomers without protecting groups. These polymers are highly effective for siRNA delivery at low doses in vitro and in vivo.
Preparation method of aliphatic mercaptan
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Paragraph 0045; 0047; 0049-0053; 0055; 0058; 0060; 0063; ..., (2021/08/28)
The invention provides a novel method for preparing (CH3CH2) 2NCH2CH2SH, wherein alkali is added when (CH3CH2) 2NH is recovered, so that the content of impurities in the recovered (CH3CH2) 2NH is reduced, and particularly, the impurities which can influence the synthesis of (CH3CH2) 2NCH2CH2SH in the recovered (CH3CH2) 2NH are removed, so that the recovered (CH3CH2) 2NH can be reused in the production of (CH3CH2) 2NCH2CH2SH.
Preparation method of aliphatic mercaptan
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Paragraph 0030; 0032-0035; 0037-0039; 0041-0042; 0044; ..., (2021/08/28)
The invention provides a novel method for preparing (CH3CH2) 2NCH2CH2SH, i.e., the reaction is carried out at a lower temperature, and the reaction is controllable by adopting a manner of dropwise adding materials, so that the safe production is realized.
Method for producing tiamulin by using diethylaminoethanethiol synthesis liquid
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Paragraph 0021; 0024; 0027, (2021/12/07)
The invention relates to a chemical synthesis method of a veterinary drug substance, in particular to a method for producing tiamulin by using low-concentration diethylaminoethanethiol. The method comprises the following steps: reacting cyclosulfane with
Microwave-assisted activation and modulator removal in zirconium MOFs for buffer-free CWA hydrolysis
Kalinovskyy,Cooper,Main,Holder,Blight
, p. 15704 - 15709 (2017/12/02)
A novel, facile and efficient method was developed for the activation of acetic acid modulated zirconium MOFs. The protocol involves briefly heating the material in water using microwave irradiation. MOF-808, DUT-84 and UiO-66 were all activated in this manner to remove the modulator and organic solvent from the framework post synthesis, with retention of MOF integrity post activation. The degree of activation was characterised by the use of TGA and NMR. The catalytic activity of the activated MOFs and their non-activated counterparts was investigated for chemical warfare agent (CWA) hydrolysis. Upon activation, an increase in the rate of hydrolysis was observed in the degradation of CWA simulant dimethyl 4-nitrophenyl phosphate (DMNP). MOF-808 and DUT-84 were also screened as catalysts for the hydrolysis of the V-series agent VM, with remarkable half-lives obtained for MOF-808 in the absence of any buffers. Currently employed MOF activation procedures involve the use of additional organic solvents post synthesis; we believe this method to be ideally efficacious for the organic desolvation of zirconium MOFs and removing modulator additives.
A diethylamino thiol preparation method
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Paragraph 0018; 0019; 0020; 0021; 0022; 0023; 0024-0029, (2017/08/25)
The invention relates to a preparation method for diethylaminoethanethiol. The preparation method comprises firstly putting ethylene sulfide in a sealed reactor, slowly stirring, adding ethene diamine, heating to 30 DEG C-40 DEG C, dropwise adding a sodiu
LIPOCATIONIC POLYMERS AND USES THEREOF
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Page/Page column 46;47, (2016/07/05)
Polymers produced by ring opening polymerization which comprises an amino group that can be used in compositions to deliver a nucleic acid such as a miRNA or a siRNA. In some embodiments, compositions which comprise the polymers described herein and a nucleic acid are also provided herein. In some embodiments, these compositions are used to silence one or more genes in vivo or treat a disease or disorder.
Synthesis technology for N,N-diethylaminoethanethiol
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Paragraph 0011, (2016/11/21)
The invention discloses a synthesis technology for N,N-diethylaminoethanethiol. The synthesis technology includes the steps of pressing ethylene sulfide and diethylamine into a pressure reaction kettle by nitrogen, heating to the temperature of 70 DEG C-9
Variants of Phosphotriesterase for the Enhanced Detoxification of the Chemical Warfare Agent VR
Bigley, Andrew N.,Mabanglo, Mark F.,Harvey, Steven P.,Raushel, Frank M.
, p. 5502 - 5512 (2015/09/15)
The V-type organophosphorus nerve agents are among the most hazardous compounds known. Previous efforts to evolve the bacterial enzyme phosphotriesterase (PTE) for the hydrolytic decontamination of VX resulted in the identification of the variant L7ep-3a,
VARIANTS OF PHOSPHOTRIESTERASE FOR THE HYDROLYSIS AND DETOXIFICATION OF NERVE AGENTS
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Paragraph 0199, (2016/05/24)
Variants of phosphotriesterase have been created that exhibit enhanced hydrolysis of V-type and G-type nerve agents over wild-type phosphotriesterase. V- and G-type nerve agents have an SP and RP enantiomer. The SP enantiomers are more toxic. V-type nerve
