780-15-4

Upstream product

• 788-21-6 3-hydroxy-4-ethyloxycarbonyl-1-phenylmethyl pyrrolidine 
• 1027-35-6 1-Benzyl-4-oxo-pyrrolidine-3-carboxylic Acid Ethyl Ester 
• 1208081-95-1 1-N-benzyl-3-hydroxy-2-pyrrolidinone-4-carboxylic acid ethyl ester 

Downstream Products

• 108026-67-1 Methanesulfonic acid 1-benzyl-4-hydroxy-pyrrolidin-3-ylmethyl ester 
• 134253-00-2 Methanesulfonic acid (3S,4S)-1-benzyl-4-methanesulfonyloxymethyl-pyrrolidin-3-yl ester 
• 134253-00-2 Methanesulfonic acid (3S,4R)-1-benzyl-4-methanesulfonyloxymethyl-pyrrolidin-3-yl ester 
• 134253-05-7 (1S,5S)-3-Benzyl-3,6-diaza-bicyclo[3.2.0]heptane 
• 134253-02-4 Methanesulfonic acid (3S,4R)-4-aminomethyl-1-benzyl-pyrrolidin-3-yl ester 
• 134253-04-6 1-((1R,5S)-3-Benzyl-3,6-diaza-bicyclo[3.2.0]hept-6-yl)-2,2,2-trifluoro-ethanone 
• 134253-03-5 Methanesulfonic acid (3S,4R)-1-benzyl-4-[(2,2,2-trifluoro-acetylamino)-methyl]-pyrrolidin-3-yl ester 
• 134253-06-8 7-((1R,5S)-3-Benzyl-3,6-diaza-bicyclo[3.2.0]hept-6-yl)-1-tert-butyl-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester 
• 125197-31-1 (3R,4S)-3-Azidomethyl-1-benzyl-4-fluoro-pyrrolidine 
• 125197-32-2 (3R,4R)-3-Azidomethyl-1-benzyl-4-fluoro-pyrrolidine 
• 108026-68-2 3-azidomethyl-1-benzyl-4-hydroxypyrrolidine 

Relevant academic research and scientific papers

DOPAMINE D3 RECEPTOR ANTAGONISTS HAVING A BICYCLO MOIETY

The disclosure provides compounds having formula (I), wherein the substituents are as defined herein. The compounds are useful for modulating the dopamine D3 receptor and for treating conditions associated therewith, such as addictions, drug dependency, and psychiatric conditions.

IMPROVED METHOD FOR PREPARING 3-HYDROXY-4-HYDROXYMETHYL-PYRROLIDINE COMPOUNDS

A process for preparing (3R,4R)-3-hydroxy-4-hydroxymethylpyrrolidine, the compound of formula (I), or (3S,4S)-3-hydroxy-4-hydroxymethylpyrrolidine, the compound of formula (Ia) involving, as a key step, the enzyme-catalysed enantioselective hydrolysis of a racemic 3,4-trans-disubstituted pyrrolidinone compound of formula (II).

Modulators of chemokine receptor activity

Chemokine receptor antagonists, in particular, bicyclic diamine compounds of Formula (I) that act as antagonists of chemokine CCR2 and CCR3 receptors including pharmaceutical compositions and uses thereof to treat or prevent diseases associated with monocyte accumulation, lymphocyte accumulation or leucocyte accumulation are described herein.

Antimicrobial 1-thienyl-4-oxoquinoline-3-carboxylic acids

Novel 1-thienyl-4-oxoquinoline-3-carboxylic acid compounds of the formula STR1 wherein R1 is an amino (lower) alkyl, R2 is thienyl, and X is a halogen atom, and a pharmaceutically acceptable salt thereof, said compounds having excell