78007-58-6Relevant articles and documents
C?C bond acylation of oxime ethers via NHC catalysis
Yang, Hai-Bin,Wan, Dan-Hong
supporting information, p. 1049 - 1053 (2021/02/01)
An N-heterocyclic carbene (NHC)-catalyzed strategy has been developed to address the issue of using toxic transitional metals in the field of C?C bond activation. The novel reaction mode enables an efficient docking between the cyanoalkyl from the cycloketone oxime derivative and the acyl group from the aldehyde, affording ketonitrile in moderate to good yields, which is one kind of useful building block for synthesizing nitrogen-containing pharmacophores.
Thermolyse von Oxazolin-5-onen, XI. N-Acylimine und Enamide durch Gasphasenpyrolyse von 4-Alkyl-2-oxazoline-5-onen
Jendrzejewski, Stefan,Steglich, Wolfgang
, p. 1337 - 1342 (2007/10/02)
On gas phase thermolysis 4-alkyl-2-oxazolin-5-ones 1 undergo CO elimination to yield N-acylimines 2, which rearrange into more stable enamides 3 if α-hydrogens are present.N-Acylimines (e.g. 2a) may be isolated in cases where the rearrangement is prevented by a quarternary C-atom.The 4,4-dialkylsubstituted oxazolinone 1o yields mixtures of N-acylimine 2o and enamide 3o, the amount of the latter increasing at higher pyrolysis temperatures.
